Technology Process of 1,2,3,4-tetrahydro-2-formyl-4-phenylthioisoquinoline
There total 6 articles about 1,2,3,4-tetrahydro-2-formyl-4-phenylthioisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: AcOH / ethanol / 20 h / Heating
2: NaBH4 / methanol / 1 h / Ambient temperature
3: 97 percent / Ac2O / 1 h / 70 °C
4: 93 percent / aq. NaIO4 / methanol / 20 h / Ambient temperature
5: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 0.5 h, 2.) benzene, RT, 2 h
With
sodium tetrahydroborate; sodium periodate; boron trifluoride diethyl etherate; acetic anhydride; acetic acid; trifluoroacetic anhydride;
In
methanol; ethanol;
DOI:10.1248/cpb.45.813
- Guidance literature:
-
Multi-step reaction with 4 steps
1: NaBH4 / methanol / 1 h / Ambient temperature
2: 97 percent / Ac2O / 1 h / 70 °C
3: 93 percent / aq. NaIO4 / methanol / 20 h / Ambient temperature
4: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 0.5 h, 2.) benzene, RT, 2 h
With
sodium tetrahydroborate; sodium periodate; boron trifluoride diethyl etherate; acetic anhydride; trifluoroacetic anhydride;
In
methanol;
DOI:10.1248/cpb.45.813
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 97 percent / Ac2O / 1 h / 70 °C
2: 93 percent / aq. NaIO4 / methanol / 20 h / Ambient temperature
3: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 0.5 h, 2.) benzene, RT, 2 h
With
sodium periodate; boron trifluoride diethyl etherate; acetic anhydride; trifluoroacetic anhydride;
In
methanol;
DOI:10.1248/cpb.45.813
