(2S)-3-(6-bromo-1H-indol-3-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

Base Information

Chemical Name:(2S)-3-(6-bromo-1H-indol-3-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid
CAS No.:97444-12-7
Molecular Formula:C₁₆H₁₉BrN₂O₄
Molecular Weight:383.242
Hs Code.:

Synonyms:(2S)-3-(6-bromo-1H-indol-3-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

Suppliers and Price of (2S)-3-(6-bromo-1H-indol-3-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
L-TRYPTOPHAN, 6-BROMO-N-[(1,1-DIMETHYLETHOXY)CARBONYL]- 95.00%
5MG
$ 503.06

American Custom Chemicals Corporation
L-TRYPTOPHAN, 6-BROMO-N-[(1,1-DIMETHYLETHOXY)CARBONYL]- 95.00%
0.25G
$ 630.00

Activate Scientific
Boc-6-Bromo-L-tryptophan 95% ee
1 g
$ 560.00

Acrotein
Boc-6-Bromo-L-tryptophan 97%
0.25g
$ 183.33

A1 Biochem Labs
Boc-6-Bromo-L-tryptophan 95%
2.5 g
$ 1000.00

A1 Biochem Labs
Boc-6-Bromo-L-tryptophan 95%
1 g
$ 550.00

Total 4 raw suppliers

Chemical Property of (2S)-3-(6-bromo-1H-indol-3-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

L-TRYPTOPHAN, 6-BROMO-N-[(1,1-DIMETHYLETHOXY)CARBONYL]- 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S)-3-(6-bromo-1H-indol-3-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

There total 7 articles about (2S)-3-(6-bromo-1H-indol-3-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 52448-17-6
(2S)-2-amino-3-(6-bromo-1H-indol-3-yl)propanoic acid

: 97444-12-7,1104606-57-6
(2S)-3-(6-bromo-1H-indol-3-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

Guidance literature:: With potassium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 16h;
DOI:10.1002/cbdv.201400406

Reference yield: 92.0%

: 691-64-5
di-tert-butyl oxalate

: 85515-06-6
N^α-acetyl-6-bromo-D,L-tryptophan

: 97444-12-7,1104606-57-6
(2S)-3-(6-bromo-1H-indol-3-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

: 97444-14-9
N^α-acetyl-6-bromo-D-tryptophan

Guidance literature:: With buffer sol.; cobalt(II) chloride; for 20h; Ambient temperature; pilzacylase;
DOI:10.1002/jlac.198519850414

Reference yield:

: 85515-06-6
N^α-acetyl-6-bromo-D,L-tryptophan

: 97444-12-7,1104606-57-6
(2S)-3-(6-bromo-1H-indol-3-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: cobalt(II) chloride hexahydrate; amano acyclase / aq. buffer / 40 h / 37 °C / pH 8 / Inert atmosphere; Enzymatic reaction

2: sodium hydroxide / 1,4-dioxane; water / 19.5 h / 20 - 80 °C / Inert atmosphere

With cobalt(II) chloride hexahydrate; amano acyclase; sodium hydroxide; In 1,4-dioxane; water;
DOI:10.1021/ol5024097