N-(3-(3-cyano-5,7-dimethylquinolin-2-ylamino)propyl)-2-methoxybenzamide

Base Information

Chemical Name:N-(3-(3-cyano-5,7-dimethylquinolin-2-ylamino)propyl)-2-methoxybenzamide
CAS No.:1356485-95-4
Molecular Formula:C₂₃H₂₄N₄O₂
Molecular Weight:388.469
Hs Code.:

Synonyms:N-(3-(3-cyano-5,7-dimethylquinolin-2-ylamino)propyl)-2-methoxybenzamide

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Chemical Property of N-(3-(3-cyano-5,7-dimethylquinolin-2-ylamino)propyl)-2-methoxybenzamide

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Technology Process of N-(3-(3-cyano-5,7-dimethylquinolin-2-ylamino)propyl)-2-methoxybenzamide

There total 5 articles about N-(3-(3-cyano-5,7-dimethylquinolin-2-ylamino)propyl)-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 917748-12-0
2-(3-aminopropylamino)-5,7-dimethylquinoline-3-carbonitrile

: 579-75-9
2-Methoxybenzoic acid

: 1356485-95-4
N-(3-(3-cyano-5,7-dimethylquinolin-2-ylamino)propyl)-2-methoxybenzamide

Guidance literature:: 2-Methoxybenzoic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

2-(3-aminopropylamino)-5,7-dimethylquinoline-3-carbonitrile; In dichloromethane; for 18h;
DOI:10.1021/jm201372q

Reference yield:

: 482639-32-7
2-chloro-5,7-dimethylquinoline-3-carbaldehyde

: 1356485-95-4
N-(3-(3-cyano-5,7-dimethylquinolin-2-ylamino)propyl)-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; triethylamine / ethanol / 3 h / Reflux

2.1: thionyl chloride / benzene / 4 h / Inert atmosphere; Reflux

3.1: 1,4-dioxane / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.5 h / 20 °C

4.2: 18 h

With thionyl chloride; hydroxylamine hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; benzene;
DOI:10.1021/jm201372q

Reference yield:

: 1356485-81-8
C₁₂H₁₁ClN₂O

: 1356485-95-4
N-(3-(3-cyano-5,7-dimethylquinolin-2-ylamino)propyl)-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / benzene / 4 h / Inert atmosphere; Reflux

2.1: 1,4-dioxane / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.5 h / 20 °C

3.2: 18 h

With thionyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; benzene;
DOI:10.1021/jm201372q