(R,E)-ethyl 5-(N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)sulfamoyl)pent-2-enoate

Base Information

Chemical Name:(R,E)-ethyl 5-(N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)sulfamoyl)pent-2-enoate
CAS No.:1380335-99-8
Molecular Formula:C₂₂H₃₃NO₆S
Molecular Weight:439.573
Hs Code.:

Synonyms:(R,E)-ethyl 5-(N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)sulfamoyl)pent-2-enoate

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Chemical Property of (R,E)-ethyl 5-(N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)sulfamoyl)pent-2-enoate

Chemical Property:

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Technology Process of (R,E)-ethyl 5-(N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)sulfamoyl)pent-2-enoate

There total 8 articles about (R,E)-ethyl 5-(N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)sulfamoyl)pent-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: C₁₈H₂₇NO₅S

: 1380335-99-8
(R,E)-ethyl 5-(N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)sulfamoyl)pent-2-enoate

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 1h; Inert atmosphere;

C₁₈H₂₇NO₅S; In tetrahydrofuran; mineral oil; at 0 - 75 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm300416h

Reference yield:

: 1198225-16-9
(R)-N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-3-hydroxy-N-(methoxymethyl)propane-1-sulfonamide

: 1380335-99-8
(R,E)-ethyl 5-(N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)sulfamoyl)pent-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 1 h / 0 - 75 °C / Inert atmosphere

With sodium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; mineral oil; 2.1: Horner-Wadsworth-Emmons olefination / 2.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm300416h

Reference yield:

: 1198223-04-9
(S,E)-N-(3-(cyclopentyloxy)benzylidene)-2-methylpropane-2-sulfinamide

: 1380335-99-8
(R,E)-ethyl 5-(N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)sulfamoyl)pent-2-enoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran; diethyl ether / 12 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 - 45 °C / Inert atmosphere

5.1: sodium iodide / N,N-dimethyl-formamide / 6 h / 20 - 90 °C / Inert atmosphere

6.1: methylamine / methanol / 1 h / 20 °C / Inert atmosphere

7.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

8.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

8.2: 1 h / 0 - 75 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; methylamine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil; 8.1: Horner-Wadsworth-Emmons olefination / 8.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm300416h