6-chloro-N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide

Base Information

Chemical Name:6-chloro-N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide
CAS No.:1429187-95-0
Molecular Formula:C₂₁H₁₉Cl₃N₂O₃
Molecular Weight:453.752
Hs Code.:

Synonyms:6-chloro-N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide

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Chemical Property of 6-chloro-N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide

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Technology Process of 6-chloro-N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide

There total 6 articles about 6-chloro-N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 3-(3,4-dichlorophenyl)propan-1-amine hydrochloride

: 1429187-94-9
6-chloro-3-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylic acid

: 1429187-95-0
6-chloro-N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide

Guidance literature:: 6-chloro-3-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 4h;

3-(3,4-dichlorophenyl)propan-1-amine hydrochloride; With triethylamine; In dichloromethane; N,N-dimethyl-formamide; for 14h;

Reference yield:

: ethyl 6-chloro-3-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate

: 1429187-95-0
6-chloro-N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol; water / 72 h / 20 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

2.2: 14 h

With oxalyl dichloride; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 25173-68-6
3(3,4-dichlorophenyl)propanoic acid

: 1429187-95-0
6-chloro-N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3.5 h / 0 - 20 °C

2.1: ammonium hydroxide / diethyl ether; water / 2.5 h / 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 7.17 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

6.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

6.2: 14 h

With hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;