(2S,3R)-3-[2-benzyloxy-5-((1S,2S)-2-benzyloxycarbonyl-1-(tert-butyl-dimethylsilanyloxy)-2-{methyl-[2-(trimethylsilanyl)ethoxycarbonyl]amino}ethyl)phenoxy]-3-methyl-2-(2-nitro-benzenesulfonylamino)-pent-4-ynoic acid tert-butyl ester

Base Information

• Chemical Name: (2S,3R)-3-[2-benzyloxy-5-((1S,2S)-2-benzyloxycarbonyl-1-(tert-butyl-dimethylsilanyloxy)-2-{methyl-[2-(trimethylsilanyl)ethoxycarbonyl]amino}ethyl)phenoxy]-3-methyl-2-(2-nitro-benzenesulfonylamino)-pent-4-ynoic acid tert-butyl ester
• CAS No.: 1001431-23-7
• Molecular Formula: C₅₂H₆₉N₃O₁₃SSi₂
• Molecular Weight: 1032.37
• Mol file: 1001431-23-7.mol

Synonyms:(2S,3R)-3-[2-benzyloxy-5-((1S,2S)-2-benzyloxycarbonyl-1-(tert-butyl-dimethylsilanyloxy)-2-{methyl-[2-(trimethylsilanyl)ethoxycarbonyl]amino}ethyl)phenoxy]-3-methyl-2-(2-nitro-benzenesulfonylamino)-pent-4-ynoic acid tert-butyl ester

Chemical Property of (2S,3R)-3-[2-benzyloxy-5-((1S,2S)-2-benzyloxycarbonyl-1-(tert-butyl-dimethylsilanyloxy)-2-{methyl-[2-(trimethylsilanyl)ethoxycarbonyl]amino}ethyl)phenoxy]-3-methyl-2-(2-nitro-benzenesulfonylamino)-pent-4-ynoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R)-3-[2-benzyloxy-5-((1S,2S)-2-benzyloxycarbonyl-1-(tert-butyl-dimethylsilanyloxy)-2-{methyl-[2-(trimethylsilanyl)ethoxycarbonyl]amino}ethyl)phenoxy]-3-methyl-2-(2-nitro-benzenesulfonylamino)-pent-4-ynoic acid tert-butyl ester

There total 1 articles about (2S,3R)-3-[2-benzyloxy-5-((1S,2S)-2-benzyloxycarbonyl-1-(tert-butyl-dimethylsilanyloxy)-2-{methyl-[2-(trimethylsilanyl)ethoxycarbonyl]amino}ethyl)phenoxy]-3-methyl-2-(2-nitro-benzenesulfonylamino)-pent-4-ynoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(2S,3S)-3-hydroxy-3-methyl-2-(2-nitro-benzenesulfonyl-amino)-pent-4-ynoic acid tert-butyl ester (1001431-19-1) + (2S,3S)-2-[2-(trimethylsilyl)ethoxycarbonylmethyl]amino-3-(3-benzyloxy-4-hydroxyphenyl)-3-(tert-butyldimethylsilyloxy)propionic acid benzyl ester (1001431-20-4) → (2S,3R)-3-[2-benzyloxy-5-((1S,2S)-2-benzyloxycarbonyl-1-(tert-butyl-dimethylsilanyloxy)-2-{methyl-[2-(trimethylsilanyl)ethoxycarbonyl]amino}ethyl)phenoxy]-3-methyl-2-(2-nitro-benzenesulfonylamino)-pent-4-ynoic acid tert-butyl ester (1001431-23-7)

Guidance literature:

With copper (I) acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 0 - 4 ℃; for 312h;

DOI:10.1002/anie.200702537

Reference yield: 92.0%

(2S,3R)-3-[2-benzyloxy-5-((1S,2S)-2-benzyloxycarbonyl-1-(tert-butyl-dimethylsilanyloxy)-2-{methyl-[2-(trimethylsilanyl)ethoxycarbonyl]amino}ethyl)phenoxy]-3-methyl-2-(2-nitro-benzenesulfonylamino)-pent-4-ynoic acid tert-butyl ester (1001431-23-7) → (2S,3R)-2-amino-3-[2-benzyloxy-5-((1S,2S)-2-benzyloxycarbonyl-1-(tert-butyl-dimethylsilanyloxy)-2-{methyl-[2-(trimethylsilanyl)ethoxycarbonyl]amino}ethyl)phenoxy]-3-methyl-pent-4-ynoic acid tert-butyl ester (1001431-32-8)

Guidance literature:

With caesium carbonate; thiophenol; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1002/anie.200702537

upstream raw materials:

(2S,3S)-3-hydroxy-3-methyl-2-(2-nitro-benzenesulfonyl-amino)-pent-4-ynoic acid tert-butyl ester

(2S,3S)-2-[2-(trimethylsilyl)ethoxycarbonylmethyl]amino-3-(3-benzyloxy-4-hydroxyphenyl)-3-(tert-butyldimethylsilyloxy)propionic acid benzyl ester

Downstream raw materials:

(2S,3R)-2-amino-3-[2-benzyloxy-5-((1S,2S)-2-benzyloxycarbonyl-1-(tert-butyl-dimethylsilanyloxy)-2-{methyl-[2-(trimethylsilanyl)ethoxycarbonyl]amino}ethyl)phenoxy]-3-methyl-pent-4-ynoic acid tert-butyl ester