(2S,3S)-3-hydroxy-3-methyl-2-(2-nitro-benzenesulfonyl-amino)-pent-4-ynoic acid tert-butyl ester

Base Information

Chemical Name:(2S,3S)-3-hydroxy-3-methyl-2-(2-nitro-benzenesulfonyl-amino)-pent-4-ynoic acid tert-butyl ester
CAS No.:1001431-19-1
Molecular Formula:C₁₆H₁₈N₂O₆S
Molecular Weight:366.395
Hs Code.:

Synonyms:(2S,3S)-3-hydroxy-3-methyl-2-(2-nitro-benzenesulfonyl-amino)-pent-4-ynoic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-3-hydroxy-3-methyl-2-(2-nitro-benzenesulfonyl-amino)-pent-4-ynoic acid tert-butyl ester

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Technology Process of (2S,3S)-3-hydroxy-3-methyl-2-(2-nitro-benzenesulfonyl-amino)-pent-4-ynoic acid tert-butyl ester

There total 1 articles about (2S,3S)-3-hydroxy-3-methyl-2-(2-nitro-benzenesulfonyl-amino)-pent-4-ynoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1001431-26-0
(2S,3R)-3-hydroxy-3-methyl-2-(2-nitro-benzenesulfonyl-amino)-pent-4-ynoic acid tert-butyl ester

: 1001431-19-1
(2S,3S)-3-hydroxy-3-methyl-2-(2-nitro-benzenesulfonyl-amino)-pent-4-ynoic acid tert-butyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1002/anie.200702537

Reference yield: 90.0%

: 123-75-1
pyrrolidine

: 1001431-19-1
(2S,3S)-3-hydroxy-3-methyl-2-(2-nitro-benzenesulfonyl-amino)-pent-4-ynoic acid tert-butyl ester

: 1243221-46-6
(2S,3R)-tert-butyl 3-methyl-2-(2-nitrophenylsulfonamido)-3-(pyrrolidin-1-yl)pent-4-ynoate

Guidance literature:: In toluene; at 20 ℃; for 1h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/ol101584z

Reference yield: 87.0%

: 1001431-19-1
(2S,3S)-3-hydroxy-3-methyl-2-(2-nitro-benzenesulfonyl-amino)-pent-4-ynoic acid tert-butyl ester

: 1001431-20-4
(2S,3S)-2-[2-(trimethylsilyl)ethoxycarbonylmethyl]amino-3-(3-benzyloxy-4-hydroxyphenyl)-3-(tert-butyldimethylsilyloxy)propionic acid benzyl ester

: 1001431-23-7
(2S,3R)-3-[2-benzyloxy-5-((1S,2S)-2-benzyloxycarbonyl-1-(tert-butyl-dimethylsilanyloxy)-2-{methyl-[2-(trimethylsilanyl)ethoxycarbonyl]amino}ethyl)phenoxy]-3-methyl-2-(2-nitro-benzenesulfonylamino)-pent-4-ynoic acid tert-butyl ester

Guidance literature:: With copper (I) acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 0 - 4 ℃; for 312h;
DOI:10.1002/anie.200702537