4-(2-ethyl-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine

Base Information

Chemical Name:4-(2-ethyl-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine
CAS No.:1187669-43-7
Molecular Formula:C₁₇H₁₇N₃S
Molecular Weight:295.408
Hs Code.:

Synonyms:4-(2-ethyl-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine

Suppliers and Price of 4-(2-ethyl-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-(2-ethyl-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(2-ethyl-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine

There total 9 articles about 4-(2-ethyl-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1187669-42-6
4-(2-ethynyl-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine

: 1187669-43-7
4-(2-ethyl-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine

Guidance literature:: With 1% Pd/C; hydrogen; In ethanol; for 16h; under 3102.97 Torr;
DOI:10.1021/jm901457w

Reference yield:

: 66572-56-3
2-bromoisonicotinic acid

: 1187669-43-7
4-(2-ethyl-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 20 °C

2.1: tetrahydrofuran; hexane / 0 °C

2.2: Saturated solution

3.1: hydrogen bromide; bromine; acetic acid / 15 - 75 °C

4.1: ethanol / 2 h / Heating; Reflux

4.2: 2 h / 20 °C / pH ~ 8

5.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 50 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C

7.1: hydrogen / palladium on activated charcoal / ethanol / 16 h / 3102.97 Torr

With copper(l) iodide; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; bromine; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; 4.1: Hantzsch thiazole synthesis;

Reference yield:

: 656257-69-1
2-bromo-N-methyl-N-(methyloxy)-4-pyridinecarboxamide

: 1187669-43-7
4-(2-ethyl-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran; hexane / 0 °C

1.2: Saturated solution

2.1: hydrogen bromide; bromine; acetic acid / 15 - 75 °C

3.1: ethanol / 2 h / Heating; Reflux

3.2: 2 h / 20 °C / pH ~ 8

4.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 50 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C

6.1: hydrogen / palladium on activated charcoal / ethanol / 16 h / 3102.97 Torr

With copper(l) iodide; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; bromine; acetic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide; 3.1: Hantzsch thiazole synthesis;