5-chloro-2-fluoro-4-{[3-(2-piperazin-1-ylpyridin-4-yl)-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

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Chemical Name:5-chloro-2-fluoro-4-{[3-(2-piperazin-1-ylpyridin-4-yl)-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide
CAS No.:1354786-52-9
Molecular Formula:C₃₂H₂₅ClF₄N₆O₃S
Molecular Weight:685.102
Hs Code.:

Synonyms:5-chloro-2-fluoro-4-{[3-(2-piperazin-1-ylpyridin-4-yl)-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

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Chemical Property of 5-chloro-2-fluoro-4-{[3-(2-piperazin-1-ylpyridin-4-yl)-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

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Technology Process of 5-chloro-2-fluoro-4-{[3-(2-piperazin-1-ylpyridin-4-yl)-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

There total 7 articles about 5-chloro-2-fluoro-4-{[3-(2-piperazin-1-ylpyridin-4-yl)-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1354787-52-2
tert-Butyl 4-(4-(4-(2-chloro-4-(N-(2,4-dimethoxybenzyl)-N-(pyrimidin-2-yl)sulfamoyl)-5-fluorophenoxy)-4'-(trifluoromethyl)biphenyl-3-yl)pyridin-2-yl)piperazine-1-carboxylate

: 1354786-52-9
5-chloro-2-fluoro-4-{[3-(2-piperazin-1-ylpyridin-4-yl)-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 20h;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1354786-52-9
5-chloro-2-fluoro-4-{[3-(2-piperazin-1-ylpyridin-4-yl)-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetra(n-butyl)ammonium hydroxide / tri tert-butylphosphoniumtetrafluoroborate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide / N,N-dimethyl-formamide; methanol / 3 h / 130 °C / Microwave irradiation; Sealed tube

2: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 18 h / 60 °C / 2585.81 Torr

3: potassium carbonate / dimethyl sulfoxide / 20 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 20 h / 20 °C

With hydrogenchloride; tetra(n-butyl)ammonium hydroxide; hydrogen; potassium carbonate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide; 10 wt% Pd(OH)2 on carbon; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Suzuki Coupling;

Reference yield:

: 89488-25-5
(5‐chloro‐2‐hydroxyphenyl)boronic acid

: 1354786-52-9
5-chloro-2-fluoro-4-{[3-(2-piperazin-1-ylpyridin-4-yl)-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 70 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

2.2: 18 h / 60 °C

3.1: potassium carbonate; tetra(n-butyl)ammonium hydroxide / tri tert-butylphosphoniumtetrafluoroborate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide / N,N-dimethyl-formamide; methanol / 3 h / 130 °C / Microwave irradiation; Sealed tube

4.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 18 h / 60 °C / 2585.81 Torr

5.1: potassium carbonate / dimethyl sulfoxide / 20 h / 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 20 h / 20 °C

With hydrogenchloride; tetra(n-butyl)ammonium hydroxide; hydrogen; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide; 10 wt% Pd(OH)2 on carbon; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: Suzuki Coupling / 3.1: Suzuki Coupling;