phenyl 2-deoxy-2-N-methyl-N-trichloroethoxycarbamoyl-1-thio-α-D-xylopyranoside

Base Information

Chemical Name:phenyl 2-deoxy-2-N-methyl-N-trichloroethoxycarbamoyl-1-thio-α-D-xylopyranoside
CAS No.:1342295-14-0
Molecular Formula:C₁₅H₁₈Cl₃NO₅S
Molecular Weight:430.737
Hs Code.:

Synonyms:phenyl 2-deoxy-2-N-methyl-N-trichloroethoxycarbamoyl-1-thio-α-D-xylopyranoside

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Chemical Property of phenyl 2-deoxy-2-N-methyl-N-trichloroethoxycarbamoyl-1-thio-α-D-xylopyranoside

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Technology Process of phenyl 2-deoxy-2-N-methyl-N-trichloroethoxycarbamoyl-1-thio-α-D-xylopyranoside

There total 7 articles about phenyl 2-deoxy-2-N-methyl-N-trichloroethoxycarbamoyl-1-thio-α-D-xylopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1342295-13-9
phenyl 2-deoxy-3,4-di-O-diethylisopropylsilyl-2-N-methyl-N-trichloroethoxycarbamoyl-1-thio-α-D-xylopyranoside

: 1342295-14-0
phenyl 2-deoxy-2-N-methyl-N-trichloroethoxycarbamoyl-1-thio-α-D-xylopyranoside

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol202639v

Reference yield:

: 1342295-08-2
phenyl 2-azido-2-deoxy-1-thio-α-D-xylopyranoside

: 1342295-14-0
phenyl 2-deoxy-2-N-methyl-N-trichloroethoxycarbamoyl-1-thio-α-D-xylopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / dichloromethane / 0 - 35 °C / Inert atmosphere

2.1: trimethylphosphane / dichloromethane; toluene / 0.75 h / Molecular sieve; Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

2.3: 1 h / 20 °C / Inert atmosphere

3.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; tetrabutyl ammonium fluoride; acetic acid; trimethylphosphane; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ol202639v

Reference yield:

: phenyl 3,4-di-O-acetyl-2-azido-2-deoxy-1-thio-D-xylopyranoside

: 1342295-14-0
phenyl 2-deoxy-2-N-methyl-N-trichloroethoxycarbamoyl-1-thio-α-D-xylopyranoside

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol; sodium methylate / 0 - 20 °C

2.1: 1H-imidazole / dichloromethane / 0 - 35 °C / Inert atmosphere

3.1: trimethylphosphane / dichloromethane; toluene / 0.75 h / Molecular sieve; Inert atmosphere

3.2: 5 h / 20 °C / Inert atmosphere

3.3: 1 h / 20 °C / Inert atmosphere

4.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; methanol; tetrabutyl ammonium fluoride; sodium methylate; acetic acid; trimethylphosphane; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ol202639v