phenyl 2-deoxy-3,4-di-O-diethylisopropylsilyl-2-N-methylamino-1-thio-α-D-xylopyranoside

Base Information

Chemical Name:phenyl 2-deoxy-3,4-di-O-diethylisopropylsilyl-2-N-methylamino-1-thio-α-D-xylopyranoside
CAS No.:1342295-11-7
Molecular Formula:C₂₆H₄₉NO₃SSi₂
Molecular Weight:511.917
Hs Code.:

Synonyms:phenyl 2-deoxy-3,4-di-O-diethylisopropylsilyl-2-N-methylamino-1-thio-α-D-xylopyranoside

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Chemical Property of phenyl 2-deoxy-3,4-di-O-diethylisopropylsilyl-2-N-methylamino-1-thio-α-D-xylopyranoside

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Technology Process of phenyl 2-deoxy-3,4-di-O-diethylisopropylsilyl-2-N-methylamino-1-thio-α-D-xylopyranoside

There total 7 articles about phenyl 2-deoxy-3,4-di-O-diethylisopropylsilyl-2-N-methylamino-1-thio-α-D-xylopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1342295-10-6
phenyl 2-azido-2-deoxy-3,4-di-O-diethylisopropylsilyl-1-thio-α-D-xylopyranoside

: 1342295-11-7
phenyl 2-deoxy-3,4-di-O-diethylisopropylsilyl-2-N-methylamino-1-thio-α-D-xylopyranoside

: 1342295-12-8
phenyl 2-amino-2-deoxy-3,4-di-O-diethylisopropylsilyl-1-thio-α-D-xylopyranoside

Guidance literature:: phenyl 2-azido-2-deoxy-3,4-di-O-diethylisopropylsilyl-1-thio-α-D-xylopyranoside; With trimethylphosphane; In dichloromethane; toluene; for 0.75h; Molecular sieve; Inert atmosphere;

formaldehyd; In dichloromethane; toluene; at 20 ℃; for 5h; Inert atmosphere;

With sodium tetrahydroborate; In methanol; dichloromethane; toluene; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol202639v

Reference yield:

: C₂₆H₄₇NO₃SSi₂

: 1342295-11-7
phenyl 2-deoxy-3,4-di-O-diethylisopropylsilyl-2-N-methylamino-1-thio-α-D-xylopyranoside

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃; for 21h; Inert atmosphere;
DOI:10.1021/ol202639v

Reference yield:

: 107149-56-4
chlorodiethylisopropylsilane

: 1342295-11-7
phenyl 2-deoxy-3,4-di-O-diethylisopropylsilyl-2-N-methylamino-1-thio-α-D-xylopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / dichloromethane / 0 - 35 °C / Inert atmosphere

2.1: trimethylphosphane / dichloromethane; toluene / 0.75 h / Molecular sieve; Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

2.3: 1 h / 20 °C / Inert atmosphere

With 1H-imidazole; trimethylphosphane; In dichloromethane; toluene;
DOI:10.1021/ol202639v