4-[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidine

Base Information

Chemical Name:4-[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidine
CAS No.:276236-97-6
Molecular Formula:C₁₃H₁₄FN₃O
Molecular Weight:247.272
Hs Code.:
DSSTox Substance ID:DTXSID201212210

Synonyms:4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidine;276236-97-6;Piperidine, 4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-;SCHEMBL4414482;DTXSID201212210;MFCD27960947;STL080983;AKOS000266082;BB 0238762;Z425834084;4-[3-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]- piperidine;4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidine hydrochloride;919345-76-9

Suppliers and Price of 4-[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidine

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:247.11209024
Heavy Atom Count:18
Complexity:265

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CNCCC1C2=NC(=NO2)C3=CC=C(C=C3)F

Technology Process of 4-[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidine

There total 5 articles about 4-[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 276236-87-4
C₁₈H₂₂FN₃O₃

: 276236-97-6
C₁₃H₁₄FN₃O

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2014.07.089

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 276236-97-6
C₁₃H₁₄FN₃O

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol / 6 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 1 h / 20 °C

3.1: N,N-dimethyl-formamide / 2 h / 110 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With hydroxylamine hydrochloride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.07.089

Reference yield:

: 22179-78-8
4-fluoro-benzamidoxime

: 276236-97-6
C₁₃H₁₄FN₃O

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 1 h / 20 °C

2.1: N,N-dimethyl-formamide / 2 h / 110 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.07.089