5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-B]quinoxaline

Base Information

Chemical Name:5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-B]quinoxaline
CAS No.:163769-88-8
Molecular Formula:C₂₂H₂₁N₃O₂
Molecular Weight:359.428
Hs Code.:2933990090
UNII:6U3RC7G5VT
DSSTox Substance ID:DTXSID30360341
Wikidata:Q27089271
ChEMBL ID:CHEMBL1356775
Mol file:163769-88-8.mol

Synonyms:2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo(7,8)indolizino (2,3-b)quinoxaline;YM-90709

Suppliers and Price of 5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-B]quinoxaline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
YM90709
100mg
$ 650.00

Tocris
YM90709 ≥99%(HPLC)
10
$ 220.00

DC Chemicals
YM90709 >98%
100 mg
$ 300.00

CSNpharm
YM-90709
10mg
$ 163.00

CSNpharm
YM-90709
5mg
$ 109.00

CSNpharm
YM-90709
25mg
$ 272.00

CSNpharm
YM-90709
50mg
$ 490.00

Crysdot
YM-90709 98+%
50mg
$ 461.00

Crysdot
YM-90709 98+%
25mg
$ 256.00

ChemScene
YM-90709 99.64%
10mg
$ 180.00

Total 17 raw suppliers

Chemical Property of 5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-B]quinoxaline

Chemical Property:

Vapor Pressure:7.97E-13mmHg at 25°C
Refractive Index:1.666
Boiling Point:579.6°Cat760mmHg
PKA:2.74±0.40(Predicted)
Flash Point:304.3°C
PSA：49.17000
Density:1.28g/cm³
LogP:4.55990
Storage Temp.:Store at RT
XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:359.16337692
Heavy Atom Count:27
Complexity:556

Purity/Quality:

99%, ^*data from raw suppliers

YM90709 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CC2=CC(=C(C=C2C3=CC4=NC5=CC=CC=C5N=C4N31)OC)OC)C
Description YM-90709 is a competitive antagonist of the interleukin-5 (IL-5) receptor that has IC50 values of 1 and 0.57 μM for peripheral human eosinophils and eosinophilic HL-60 clone 15 cells, respectively, in a radioligand binding assay. It inhibits IL-5-induced eosinophil survival (IC50 = 0.45 μM) and JAK2 phosphorylation in vitro. YM-90709 inhibits eosinophil and lymphocyte infiltration (ED50s = 0.32 and 0.12 mg/kg, respectively) into the brochoalveolar lavage fluid (BALF) of rats and eosinophil infiltration (ED50 = 0.05 mg/kg) into the BALF of mice in models of airway inflammation.
Uses YM 90709, is an interleukin-5 receptor antagonist.

Technology Process of 5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-B]quinoxaline

There total 2 articles about 5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-B]quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 95-54-5
1,2-diamino-benzene

: 163769-81-1
8,9-Dimethoxy-5,5-dimethyl-5,6-dihydro-pyrrolo[2,1-a]isoquinoline-2,3-dione

: 163769-88-8
5,5-dimethyl-2,3,5,6-tetrahydro-(3,4-dimethoxybenzo)quinoxalino<2,3-b>indolizine

Guidance literature:: With acetic acid; for 2h; Heating;
DOI:10.1007/BF01169639

Reference yield:

: 121064-15-1
1,3,3-trimethyl-6,7-dimethoxy-3,4-dihydroisoquinoline

: 163769-88-8
5,5-dimethyl-2,3,5,6-tetrahydro-(3,4-dimethoxybenzo)quinoxalino<2,3-b>indolizine

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / Et₃N / diethyl ether / 2.33 h / 0 - 20 °C

2: 47 percent / glacial acetic acid / 2 h / Heating

With acetic acid; triethylamine; In diethyl ether;
DOI:10.1007/BF01169639