(6-{5-[3-(tert-butyl-diphenyl-silanyloxy)-propylamino]-2-fluoro-pyridin-3-yl}-pyrazin-2-yl)-(3-chloro-phenyl)-carbamic acid tert-butyl ester

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Chemical Name:(6-{5-[3-(tert-butyl-diphenyl-silanyloxy)-propylamino]-2-fluoro-pyridin-3-yl}-pyrazin-2-yl)-(3-chloro-phenyl)-carbamic acid tert-butyl ester
CAS No.:405939-80-2
Molecular Formula:C₃₉H₄₃ClFN₅O₃Si
Molecular Weight:712.339
Hs Code.:

(6-{5-[3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-propylamino]-2-fluoro-pyridin-3-yl}-pyrazin-2-yl)-(3-chloro-phenyl)-carbamic acid <i>tert</i>-butyl ester

Synonyms:(6-{5-[3-(tert-butyl-diphenyl-silanyloxy)-propylamino]-2-fluoro-pyridin-3-yl}-pyrazin-2-yl)-(3-chloro-phenyl)-carbamic acid tert-butyl ester

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Chemical Property of (6-{5-[3-(tert-butyl-diphenyl-silanyloxy)-propylamino]-2-fluoro-pyridin-3-yl}-pyrazin-2-yl)-(3-chloro-phenyl)-carbamic acid tert-butyl ester

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Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (6-{5-[3-(tert-butyl-diphenyl-silanyloxy)-propylamino]-2-fluoro-pyridin-3-yl}-pyrazin-2-yl)-(3-chloro-phenyl)-carbamic acid tert-butyl ester

There total 6 articles about (6-{5-[3-(tert-butyl-diphenyl-silanyloxy)-propylamino]-2-fluoro-pyridin-3-yl}-pyrazin-2-yl)-(3-chloro-phenyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 405939-53-9
[6-(5-{benzyloxycarbonyl-[3-(tert-butyldiphenylsilanyloxy)propyl]amino}-2-fluoropyridin-3-yl)pyrazin-2-yl]-(3-chlorophenyl)carbamic acid tert-butyl ester

: 405939-80-2
(6-{5-[3-(tert-butyl-diphenyl-silanyloxy)-propylamino]-2-fluoro-pyridin-3-yl}-pyrazin-2-yl)-(3-chloro-phenyl)-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; at 20 ℃; for 46h; under 1137.73 Torr;
DOI:10.1021/jm058205b

Reference yield:

: 405940-12-7
(3-chlorophenyl)(6-chloropyrazin-2-yl)carbamic acid tert-butyl ester

: 405939-80-2
(6-{5-[3-(tert-butyl-diphenyl-silanyloxy)-propylamino]-2-fluoro-pyridin-3-yl}-pyrazin-2-yl)-(3-chloro-phenyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis(trimethyltin); 2,6-di-tert-butyl-4-methylphenol; LiCl / tetrakis(triphenylphosphine)palladium / dioxane / 4.5 h / 100 °C

1.2: 140 mg / dichlorobis-(triphenylphosphine)palladium; LiCl / toluene / 19 h / 100 °C

2.1: 65 percent / H₂ / Pd/C / ethanol; ethyl acetate / 46 h / 20 °C / 1137.73 Torr

With 2,6-di-tert-butyl-4-methyl-phenol; hydrogen; hexamethyldistannane; lithium chloride; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; ethyl acetate; 1.2: Stille coupling;
DOI:10.1021/jm058205b

Reference yield:

: 405939-48-2
(6-amino-5-bromopyridin-3-yl)carbamic acid benzyl ester

: 405939-80-2
(6-{5-[3-(tert-butyl-diphenyl-silanyloxy)-propylamino]-2-fluoro-pyridin-3-yl}-pyrazin-2-yl)-(3-chloro-phenyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 81 percent / Cs₂CO₃ / dimethylformamide / 3 h / 70 °C

2.1: 62 percent / nitrosonium tetrafluoroborate / CH₂Cl₂ / 3 h / 4 °C

3.1: bis(trimethyltin); 2,6-di-tert-butyl-4-methylphenol; LiCl / tetrakis(triphenylphosphine)palladium / dioxane / 4.5 h / 100 °C

3.2: 140 mg / dichlorobis-(triphenylphosphine)palladium; LiCl / toluene / 19 h / 100 °C

4.1: 65 percent / H₂ / Pd/C / ethanol; ethyl acetate / 46 h / 20 °C / 1137.73 Torr

With 2,6-di-tert-butyl-4-methyl-phenol; hydrogen; hexamethyldistannane; caesium carbonate; nitrosonium tetrafluoroborate; lithium chloride; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 3.2: Stille coupling;
DOI:10.1021/jm058205b