Benzyl (6-amino-5-bromopyridin-3-yl)carbamate

Base Information

Chemical Name:Benzyl (6-amino-5-bromopyridin-3-yl)carbamate
CAS No.:405939-48-2
Molecular Formula:C13H12BrN3O2
Molecular Weight:322.161
Hs Code.:
DSSTox Substance ID:DTXSID40463892
Wikidata:Q82288979
Mol file:405939-48-2.mol

Synonyms:Benzyl (6-amino-5-bromopyridin-3-yl)carbamate;405939-48-2;benzyl N-(6-amino-5-bromopyridin-3-yl)carbamate;DTXSID40463892;A873282;(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINEHEMIHYDRATE

Suppliers and Price of Benzyl (6-amino-5-bromopyridin-3-yl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-BROMO-2,5-DIAMINO PYRIDINE, 5-CBZ PROTECTED 95.00%
5MG
$ 501.66

Total 6 raw suppliers

Chemical Property of Benzyl (6-amino-5-bromopyridin-3-yl)carbamate

Chemical Property:

Vapor Pressure:4.86E-07mmHg at 25°C
Boiling Point:413.3oC at 760 mmHg
PKA:11.82±0.70(Predicted)
Flash Point:203.7oC
PSA：77.24000
Density:1.6g/cm3
LogP:3.82920
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:321.01129
Heavy Atom Count:19
Complexity:298

Purity/Quality:

97% ^*data from raw suppliers

3-BROMO-2,5-DIAMINO PYRIDINE, 5-CBZ PROTECTED 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC(=O)NC2=CC(=C(N=C2)N)Br

Technology Process of Benzyl (6-amino-5-bromopyridin-3-yl)carbamate

There total 1 articles about Benzyl (6-amino-5-bromopyridin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 3167-49-5
6-aminonicotinic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 405939-48-2
(6-amino-5-bromopyridin-3-yl)carbamic acid benzyl ester

: 35486-42-1
2-amino-3,5-dibromopyridine

Guidance literature:: 6-aminonicotinic acid; With water; bromine; at 20 ℃; for 4.5h;

benzyl alcohol; With diphenylphosphoranyl azide; triethylamine; In toluene; at 70 - 100 ℃; for 2h;
DOI:10.1021/jm058205b

Reference yield: 81.0%

: 405939-48-2
(6-amino-5-bromopyridin-3-yl)carbamic acid benzyl ester

: 177338-13-5
3-(tert-butyldiphenylsilyloxy)propyl bromide

: 405939-49-3
(6-amino-5-bromopyridin-3-yl)-[3-(tert-butyldiphenylsilanyloxy)propyl]carbamic acid benzyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 3h;
DOI:10.1021/jm058205b

Reference yield:

: 405939-48-2
(6-amino-5-bromopyridin-3-yl)carbamic acid benzyl ester

: 3-{6-amino-5-[6-(3-chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-ylamino}-propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 81 percent / Cs₂CO₃ / dimethylformamide / 3 h / 70 °C

2.1: bis(trimethyltin); 2,6-di-tert-butyl-4-methylphenol; LiCl / tetrakis(triphenylphosphine)palladium / dioxane / 3 h / 100 °C

2.2: 830 mg / dichlorobis-(triphenylphosphine)palladium; LiCl / toluene / 2.5 h / 100 °C

3.1: 76 percent / CF₃SO₃H / CH₂Cl₂ / 1.5 h / 20 °C

With trifluorormethanesulfonic acid; 2,6-di-tert-butyl-4-methyl-phenol; hexamethyldistannane; caesium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 2.2: Stille coupling;
DOI:10.1021/jm058205b