phenylmethyl N-[3-[4-[3-chloro-1,6-dihydro-1-[(2S)-2-methylbutyl]-6-oxo-5-(1H-pyrazol-1-yl)-2-pyrazinyl]-3,5-difluorophenoxy]propyl]-N-methylcarbamate

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Chemical Name:phenylmethyl N-[3-[4-[3-chloro-1,6-dihydro-1-[(2S)-2-methylbutyl]-6-oxo-5-(1H-pyrazol-1-yl)-2-pyrazinyl]-3,5-difluorophenoxy]propyl]-N-methylcarbamate
CAS No.:1000197-92-1
Molecular Formula:C₃₀H₃₂ClF₂N₅O₄
Molecular Weight:600.065
Hs Code.:

Synonyms:phenylmethyl N-[3-[4-[3-chloro-1,6-dihydro-1-[(2S)-2-methylbutyl]-6-oxo-5-(1H-pyrazol-1-yl)-2-pyrazinyl]-3,5-difluorophenoxy]propyl]-N-methylcarbamate

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Chemical Property of phenylmethyl N-[3-[4-[3-chloro-1,6-dihydro-1-[(2S)-2-methylbutyl]-6-oxo-5-(1H-pyrazol-1-yl)-2-pyrazinyl]-3,5-difluorophenoxy]propyl]-N-methylcarbamate

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Technology Process of phenylmethyl N-[3-[4-[3-chloro-1,6-dihydro-1-[(2S)-2-methylbutyl]-6-oxo-5-(1H-pyrazol-1-yl)-2-pyrazinyl]-3,5-difluorophenoxy]propyl]-N-methylcarbamate

There total 8 articles about phenylmethyl N-[3-[4-[3-chloro-1,6-dihydro-1-[(2S)-2-methylbutyl]-6-oxo-5-(1H-pyrazol-1-yl)-2-pyrazinyl]-3,5-difluorophenoxy]propyl]-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 5-chloro-6-(2,6-difluoro-4-hydroxyphenyl)-1-((2S)-2-methylbutyl)-3-(1H-pyrazol-1-yl)-2(1H)-pyrazinone

: 1000197-91-0
phenylmethyl N-(3-chloropropyl)-N-methylcarbamate

: 1000197-92-1
phenylmethyl N-[3-[4-[3-chloro-1,6-dihydro-1-[(2S)-2-methylbutyl]-6-oxo-5-(1H-pyrazol-1-yl)-2-pyrazinyl]-3,5-difluorophenoxy]propyl]-N-methylcarbamate

Guidance literature:: 5-chloro-6-(2,6-difluoro-4-hydroxyphenyl)-1-((2S)-2-methylbutyl)-3-(1H-pyrazol-1-yl)-2(1H)-pyrazinone; phenylmethyl N-(3-chloropropyl)-N-methylcarbamate; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Molecular sieve; Inert atmosphere;

With caesium carbonate; In N,N-dimethyl-formamide; for 2h; Molecular sieve; Heating; Inert atmosphere;
DOI:10.1016/j.bmc.2015.08.038

Reference yield:

: 1000197-91-0
phenylmethyl N-(3-chloropropyl)-N-methylcarbamate

: 1000197-92-1
phenylmethyl N-[3-[4-[3-chloro-1,6-dihydro-1-[(2S)-2-methylbutyl]-6-oxo-5-(1H-pyrazol-1-yl)-2-pyrazinyl]-3,5-difluorophenoxy]propyl]-N-methylcarbamate

Guidance literature:: 5-chloro-6-(2,6-difluoro-4-hydroxyphenyl)-1-((2S)-2-methylbutyl)-3-(1H-pyrazol-1-yl)-2(1H)-pyrazinone; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Molecular sieve;

phenylmethyl N-(3-chloropropyl)-N-methylcarbamate; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

With caesium carbonate; In N,N-dimethyl-formamide; at 20 - 75 ℃; for 2.25h;

Reference yield:

: 34985-37-0
(S)-2-methylbutylamine

: 1000197-92-1
phenylmethyl N-[3-[4-[3-chloro-1,6-dihydro-1-[(2S)-2-methylbutyl]-6-oxo-5-(1H-pyrazol-1-yl)-2-pyrazinyl]-3,5-difluorophenoxy]propyl]-N-methylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogensulfite / water; methanol / 0.25 h / 20 °C

1.2: 0.33 h / 20 °C

1.3: 2.25 h / 0 - 35 °C

2.1: chlorobenzene / 100 °C

2.2: 2 h / 100 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / Heating

4.1: boron tribromide / dichloromethane / -78 - 20 °C

5.1: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 0.25 h / 20 °C / Molecular sieve; Inert atmosphere

5.2: 2 h / Molecular sieve; Heating; Inert atmosphere

With boron tribromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium hydrogensulfite; In methanol; dichloromethane; water; N,N-dimethyl-formamide; chlorobenzene; 1.1: |Strecker Aminoacid Synthesis / 1.2: |Strecker Aminoacid Synthesis / 1.3: |Strecker Aminoacid Synthesis;
DOI:10.1016/j.bmc.2015.08.038