1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-O-isopropylidene-1(R,S),3(S),4-butanetriol

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Chemical Name:1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-O-isopropylidene-1(R,S),3(S),4-butanetriol
CAS No.:250214-22-3
Molecular Formula:C₂₇H₄₁O₆PSi
Molecular Weight:520.678
Hs Code.:

Synonyms:1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-O-isopropylidene-1(R,S),3(S),4-butanetriol

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Chemical Property of 1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-O-isopropylidene-1(R,S),3(S),4-butanetriol

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Technology Process of 1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-O-isopropylidene-1(R,S),3(S),4-butanetriol

There total 3 articles about 1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-O-isopropylidene-1(R,S),3(S),4-butanetriol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 250214-21-2
1-diethylphosphonyl-3,4-O-isopropylidene-1(R,S),3(S),4-butanetriol

: 250214-22-3
1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-O-isopropylidene-1(R,S),3(S),4-butanetriol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0040-4020(99)00681-X

Reference yield:

: 32233-43-5
2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol

: 250214-22-3
1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-O-isopropylidene-1(R,S),3(S),4-butanetriol

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / PDC / CH₂Cl₂ / 20 °C

2: 58 percent / LiN(TMS)2 / tetrahydrofuran / 16 h / -78 - 20 °C

3: 84 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; dipyridinium dichromate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Oxidation / 2: Addition / 3: silylation;
DOI:10.1016/S0040-4020(99)00681-X

Reference yield:

: 32233-44-6
2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]acetaldehyde

: 250214-22-3
1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-O-isopropylidene-1(R,S),3(S),4-butanetriol

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / LiN(TMS)2 / tetrahydrofuran / 16 h / -78 - 20 °C

2: 84 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Addition / 2: silylation;
DOI:10.1016/S0040-4020(99)00681-X