1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-bis-O-methanesulfonyl-1(R,S),3(S),4-butanetriol

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Chemical Name:1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-bis-O-methanesulfonyl-1(R,S),3(S),4-butanetriol
CAS No.:250214-24-5
Molecular Formula:C₂₆H₄₁O₁₀PS₂Si
Molecular Weight:636.797
Hs Code.:

Synonyms:1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-bis-O-methanesulfonyl-1(R,S),3(S),4-butanetriol

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Chemical Property of 1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-bis-O-methanesulfonyl-1(R,S),3(S),4-butanetriol

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Technology Process of 1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-bis-O-methanesulfonyl-1(R,S),3(S),4-butanetriol

There total 3 articles about 1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-bis-O-methanesulfonyl-1(R,S),3(S),4-butanetriol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 124-63-0
methanesulfonyl chloride

: 250214-23-4
1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-1(R,S),3(S),4-butanetriol

: 250214-24-5
1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-bis-O-methanesulfonyl-1(R,S),3(S),4-butanetriol

Guidance literature:: With triethylamine; In dichloromethane; for 24h; freezer;
DOI:10.1016/S0040-4020(99)00681-X

Reference yield:

: 250214-21-2
1-diethylphosphonyl-3,4-O-isopropylidene-1(R,S),3(S),4-butanetriol

: 250214-24-5
1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-bis-O-methanesulfonyl-1(R,S),3(S),4-butanetriol

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / imidazole / dimethylformamide / 20 °C

2: 79 percent / 0.6 percent HCl / acetonitrile / 20 °C / pH 1.5

3: 89 percent / Et₃N / CH₂Cl₂ / 24 h / freezer

With 1H-imidazole; hydrogenchloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: silylation / 2: Ring cleavage / 3: mesylation;
DOI:10.1016/S0040-4020(99)00681-X

Reference yield:

: 250214-22-3
1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-O-isopropylidene-1(R,S),3(S),4-butanetriol

: 250214-24-5
1-diethylphosphonyl-1-O-tert-butyldiphenylsilyl-3,4-bis-O-methanesulfonyl-1(R,S),3(S),4-butanetriol

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / 0.6 percent HCl / acetonitrile / 20 °C / pH 1.5

2: 89 percent / Et₃N / CH₂Cl₂ / 24 h / freezer

With hydrogenchloride; triethylamine; In dichloromethane; acetonitrile; 1: Ring cleavage / 2: mesylation;
DOI:10.1016/S0040-4020(99)00681-X