(E)-3-{5-{{[2-(benzo[d][1,3]dioxol-5-yl)ethyl](4-phenoxybutyl)amino}methyl}furan-2-yl}-N-hydroxyacrylamide

Base Information

Chemical Name:(E)-3-{5-{{[2-(benzo[d][1,3]dioxol-5-yl)ethyl](4-phenoxybutyl)amino}methyl}furan-2-yl}-N-hydroxyacrylamide
CAS No.:1450591-60-2
Molecular Formula:C₂₇H₃₀N₂O₆
Molecular Weight:478.545
Hs Code.:

Synonyms:(E)-3-{5-{{[2-(benzo[d][1,3]dioxol-5-yl)ethyl](4-phenoxybutyl)amino}methyl}furan-2-yl}-N-hydroxyacrylamide

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Chemical Property of (E)-3-{5-{{[2-(benzo[d][1,3]dioxol-5-yl)ethyl](4-phenoxybutyl)amino}methyl}furan-2-yl}-N-hydroxyacrylamide

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Technology Process of (E)-3-{5-{{[2-(benzo[d][1,3]dioxol-5-yl)ethyl](4-phenoxybutyl)amino}methyl}furan-2-yl}-N-hydroxyacrylamide

There total 5 articles about (E)-3-{5-{{[2-(benzo[d][1,3]dioxol-5-yl)ethyl](4-phenoxybutyl)amino}methyl}furan-2-yl}-N-hydroxyacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.2%

: 1450591-23-7
(E)-ethyl 3-{5-{{[2-(benzo[d][1,3]dioxol-5-yl)ethyl](2-phenoxybutyl)amino}methyl}furan-2-yl}acrylate

: 1450591-60-2
(E)-3-{5-{{[2-(benzo[d][1,3]dioxol-5-yl)ethyl](4-phenoxybutyl)amino}methyl}furan-2-yl}-N-hydroxyacrylamide

Guidance literature:: With hydroxylamine; potassium hydroxide; In methanol; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2013.06.009

Reference yield:

: 53282-12-5,53282-26-1
ethyl (E)-3-(2-furyl)prop-2-enoate

: 1450591-60-2
(E)-3-{5-{{[2-(benzo[d][1,3]dioxol-5-yl)ethyl](4-phenoxybutyl)amino}methyl}furan-2-yl}-N-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate; N,N-dimethyl-formamide / 2.33 h / 0 - 60 °C

2: methanol / 3 h / Reflux

3: sodium tetrahydroborate / methanol / 0.5 h / 20 °C

4: potassium iodide; potassium carbonate / acetonitrile / 8 h / 35 °C

5: hydroxylamine; potassium hydroxide / methanol / 1 h / 20 °C

With sodium tetrahydroborate; hydroxylamine; potassium carbonate; N,N-dimethyl-formamide; potassium iodide; potassium hydroxide; trichlorophosphate; In methanol; acetonitrile;
DOI:10.1016/j.bmc.2013.06.009

Reference yield:

: C₁₉H₁₉NO₅

: 1450591-60-2
(E)-3-{5-{{[2-(benzo[d][1,3]dioxol-5-yl)ethyl](4-phenoxybutyl)amino}methyl}furan-2-yl}-N-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol / 0.5 h / 20 °C

2: potassium iodide; potassium carbonate / acetonitrile / 8 h / 35 °C

3: hydroxylamine; potassium hydroxide / methanol / 1 h / 20 °C

With sodium tetrahydroborate; hydroxylamine; potassium carbonate; potassium iodide; potassium hydroxide; In methanol; acetonitrile;
DOI:10.1016/j.bmc.2013.06.009