(E)-2-Methyl-pentadec-2-enoic acid (1R,2S,3S)-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-4-trityloxy-butyl ester

Base Information

Chemical Name:(E)-2-Methyl-pentadec-2-enoic acid (1R,2S,3S)-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-4-trityloxy-butyl ester
CAS No.:331625-81-1
Molecular Formula:C₆₄H₇₈O₉
Molecular Weight:991.318
Hs Code.:

Synonyms:(E)-2-Methyl-pentadec-2-enoic acid (1R,2S,3S)-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-4-trityloxy-butyl ester

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Chemical Property of (E)-2-Methyl-pentadec-2-enoic acid (1R,2S,3S)-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-4-trityloxy-butyl ester

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Technology Process of (E)-2-Methyl-pentadec-2-enoic acid (1R,2S,3S)-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-4-trityloxy-butyl ester

There total 6 articles about (E)-2-Methyl-pentadec-2-enoic acid (1R,2S,3S)-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-4-trityloxy-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: trans-2-methyl-2-pentadecenoic acid

: 331625-55-9
(2R,3R,4S)-1,3,4-Tris-(4-methoxy-benzyloxy)-5-trityloxy-pentan-2-ol

: 331625-81-1
(E)-2-Methyl-pentadec-2-enoic acid (1R,2S,3S)-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-4-trityloxy-butyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 2.5h; Heating;
DOI:10.1021/ja0057272

Reference yield:

: 532-20-7,613-83-2,7261-25-8,7687-39-0,13221-22-2,14795-83-6,15761-67-8,20074-49-1,25545-03-3,25545-04-4,32445-75-3,34436-17-4,36441-93-7,36468-53-8,37110-85-3,37388-49-1,38029-69-5,40461-77-6,40461-89-0,41546-19-4,41546-20-7,41546-21-8,41546-26-3,41546-29-6,41546-30-9,41546-31-0,126872-16-0,131064-98-7
D-Ribose

: 331625-81-1
(E)-2-Methyl-pentadec-2-enoic acid (1R,2S,3S)-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-4-trityloxy-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂SO₄ / 12 h / 4 °C

2: 4.49 g / Bu₄NBr; KOH / tetrahydrofuran; H₂O / 5 h / 90 °C

3: 87 percent / DIBAL; [1,3-bis(diphenylphosphino)propane]dichloronickel(II) / diethyl ether; hexane / 6 h / 20 °C

4: 94 percent / Et₃N / CH₂Cl₂ / 15 h / 20 °C

5: 84 percent / DCC; DMAP / CH₂Cl₂ / 2.5 h / Heating

With dmap; potassium hydroxide; [1,3-bis(diphenylphosphino)propane]dichloronickel(II); sulfuric acid; tetrabutylammomium bromide; diisobutylaluminium hydride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water;
DOI:10.1021/ja0057272

Reference yield:

: 76-83-5
trityl chloride

: 331625-81-1
(E)-2-Methyl-pentadec-2-enoic acid (1R,2S,3S)-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-4-trityloxy-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 15 h / 20 °C

2: 84 percent / DCC; DMAP / CH₂Cl₂ / 2.5 h / Heating

With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/ja0057272