(S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

Base Information

• Chemical Name: (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester
• CAS No.: 160885-43-8
• Molecular Formula: C₄₅H₄₃N₃O₇
• Molecular Weight: 737.852
• Mol file: 160885-43-8.mol

Synonyms:(S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

Chemical Property of (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

There total 4 articles about (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-D-MeAla-Cl (144073-16-5) + (S)-Tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester (160885-42-7) → (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester (160885-43-8)

Guidance literature:

With silver cyanide; In toluene; at 70 ℃; for 1h; Yield given;

DOI:10.1016/S0040-4039(00)78375-4

Reference yield:

(2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl](methyl)amino}propanoic acid → (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester (160885-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (COCl)2 / CH₂Cl₂ / 2 h / 25 °C

2: AgCN / toluene / 1 h / 70 °C

With silver cyanide; oxalyl dichloride; In dichloromethane; toluene;

DOI:10.1016/S0040-4039(00)78375-4

Reference yield:

(3S)-hexahydro-1,3-pridazinedicarboxylic acid 1-(phenylmethyl) ester (65632-62-4) → (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester (160885-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone / 0 °C

2: AgCN / toluene / 1 h / 70 °C

With silver cyanide; In acetone; toluene;

DOI:10.1016/S0040-4039(00)78375-4

upstream raw materials:

Fmoc-D-MeAla-Cl

(S)-Tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

(3S)-hexahydro-1,3-pridazinedicarboxylic acid 1-(phenylmethyl) ester

diazodiphenylmethane

Downstream raw materials:

C₆₆H₈₁N₇O₁₄Si

C₅₁H₇₁N₇O₁₂Si

(S)-3-[(1R,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxycarbonyl-propylcarbamoyl]-2-{(R)-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

(S)-3-[(1R,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxycarbonyl-propylcarbamoyl]-2-((R)-2-methylamino-propionyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester