65632-62-4

Basic information

• Product Name: (S)-1-(Benzyloxycarbonyl)hexahydropyridazine-3-carboxylic acid
• Synonyms: (s)-tetrahydro-1,3(2h)-pyridazinedicarboxylic acid 1-(phenylmethyl) ester;(s)-1-(benzyloxycarbonyl)hexahydropyridazine-3-carboxylic acid;(S)-1-(Benxyloxycarbonyl)hexahydropyridazine-3-carboxylic acid;(S)-1-(benzyloxycarbonyl)piperazine-3-carboxylic acid;(Benzyloxycarbonyl)hexahydropyridazine-3-carboxylic acid;(S)-1-(Benzyloxycarbonyl)hexahydropyridazine-3-carboxylic acid, >=98%;(3S)-1-phenylmethoxycarbonyldiazinane-3-carboxylic acid;1,3(2H)-Pyridazinedicarboxylic acid, tetrahydro-, 1-(phenylmethyl) ester, (S)-
• CAS NO: 65632-62-4
• Molecular Formula: C₁₃H₁₆N₂O₄
• Molecular Weight: 264.28
• Mol File: 65632-62-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 168-169°C
• Boiling Point: 440°C
• Flash Point: 220.011 °C
• Appearance: /
• Density: 1.294
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.07±0.20(Predicted)
• CAS DataBase Reference: (S)-1-(Benzyloxycarbonyl)hexahydropyridazine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(Benzyloxycarbonyl)hexahydropyridazine-3-carboxylic acid(65632-62-4)
• EPA Substance Registry System: (S)-1-(Benzyloxycarbonyl)hexahydropyridazine-3-carboxylic acid(65632-62-4)

Safety Data

• Hazardous Substances Data: 65632-62-4(Hazardous Substances Data)

Usage

General Description

"(S)-1-(Benzyloxycarbonyl)hexahydropyridazine-3-carboxylic acid" is a chemical compound that falls under the category of organic compounds. As its name suggests, it consists of various groups including a benzyloxycarbonyl group, a hexahydropyridazine group, and a carboxylic acid group. The presence of these groups influences its chemical behavior and its potential applications in diverse fields such as chemical synthesis, pharmaceuticals, and other chemical industries. The exact properties of this compound such as its physical properties, toxicity, reactivity, and environmental impact can be determined through detailed experimentation and data analysis. Being a complex organic compound, it may have a stereocenter - hence the specification of (S) in the name, which refers to a particular spatial arrangement of the atoms.

InChI:InChI=1/C13H16N2O4/c16-12(17)11-7-4-8-15(14-11)13(18)19-9-10-5-2-1-3-6-10/h1-3,5-6,11,14H,4,7-9H2,(H,16,17)/t11-/m0/s1

Upstream product

• 2449-05-0 dibenzyl azodicarboxylate 
• 1191-30-6 5-bromopentanal 
• 176237-46-0 isopropyl (S)-2-(2-acetyl-1-benzyloxycarbonylhydrazino)-5-(methanesulfonyloxy)pentanoate 
• 176237-45-9 isopropyl (S)-2-(benzyloxycarbonylamino)-5-(methanesulfonyloxy)pentanoate 
• 176237-43-7 N-benzyloxycarbonyl-L-pyroglutamic acid isopropyl ester 
• 156699-38-6 (4S)-3-<(3S)-N,N'-bis(t-butoxycarbonyl)hexahydropyridazine-3-carboxy>-4-phenylmethyl-2-oxazolidinone 
• 156699-39-7 (3S)-N,N'-bis-(t-butoxycarbonyl)hexahydropyridazine-3-carboxylic acid 
• 156699-37-5 (S)-4-benzyl-3-(5-bromopentanoyl)oxazolidine-2-one 
• 4509-90-4 5-bromovaleroyl chloride 
• 672307-41-4 phenylmethyl (3S)-hexahydro-3-[[(4S)-2-oxo-4-(phenylmethyl)-3-oxazolidinyl]carbonyl]-1-pyridazinecarboxylate 
• 501-53-1 benzyl chloroformate 
• 176237-47-1 isopropyl (S)-1-acetyl-2-benzyloxycarbonylhexahydropyridazine-3-carboxylate 
• 61177-53-5 (S)-N-Benzyloxycarbonylpyroglutamic acid chloride 

Downstream Products

• 1161076-94-3 phenylmethyl 2-(4-fluorophenyl)-5,6-dihydro-3-[2-[(2-hydroxy-1-methylethyl)amino]-4-pyrimidinyl]pyrazolo[1,5-b]pyridazine-7(4H)-carboxylate 
• 1161076-93-2 phenylmethyl 3-[2-(cyclopropylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate 
• 1161076-46-5 phenylmethyl 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate 
• 1161076-92-1 4,5,6,7-tetrahydro-3-hydroxy-7-[(phenylmethoxy)carbonyl][1,2,3]oxadiazolo[3,4-b]pyridazin-8-ium inner salt 
• 1161076-91-0 1-(phenylmethyl) hydrogen tetrahydro-2-nitrosopyridazine-1,(3S)(2H)-dicarboxylate 
• 439292-93-0 (3S)-N⁽¹⁾-Z-piperazic acid t-butylhydrazide 
• 160885-46-1 C₆₆H₈₁N₇O₁₄Si 
• 186522-59-8 C₅₁H₇₁N₇O₁₂Si 
• 160885-45-0 (S)-3-[(1R,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxycarbonyl-propylcarbamoyl]-2-{(R)-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester 
• 160885-43-8 (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester 
• 160885-44-9 (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 
• 160885-40-5 (S)-3-[(1R,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxycarbonyl-propylcarbamoyl]-2-((R)-2-methylamino-propionyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester 
• 234752-71-7 3-[(9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carbonyl)-amino]-N-methoxy-N-methyl-succinamic acid tert-butyl ester 
• 192755-43-4 3-[(9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carbonyl)-amino]-4-oxo-butyric acid tert-butyl ester 

Relevant articles and documents

A scalable process to the key intermediate of cilazapril, (S)-1-benzyloxycarbonylhexahydropyridazine-3-carboxylic acid, through a novel cascade course

A novel and efficient manufacturing technology is disclosed in the present work for the preparation of (S)-1-benzyloxycarbonylhexahydropyridazine-3- carboxylic acid, which is a key intermediate of cilazapril. The whole process includes only three steps; the first two steps were conducted in one pot, followed by a novel selective removal of a Cbz group in a cascade course.

Stereochemical Definition and Chirospecific Synthesis of the Peptide Deformylase Inhibitor Sch 382583

The recently reported natural product Sch 382583 (1), an inhibitor of peptide deformylase, has been synthesized in 16 steps from commercially available starting materials. The three chiral centers were set by a combination of chiral auxiliary and chiral p

Enantioselective syntheses of (R)- and (S)-hexahydropyridazine-3-carboxylic acid derivatives

Appropriately protected optically active tetrahydropyridazine-3-carboxylic acid and hexahydropyridazine-3-carboxylic acid were prepared via ring closure of α-hydrazino- and δ-hydrazinopentanoates. Either optically active glutamic acid or an enantioselective catalytic hydrogenation was used to generate the chiral center. The numerous optically active intermediates are valuable starting materials for the synthesis of other unusual amino acids.