N-benzyl N-(tert-butoxycarbonyl) iso-propylsulfonamide

Base Information

• Chemical Name: N-benzyl N-(tert-butoxycarbonyl) iso-propylsulfonamide
• CAS No.: 808148-14-3
• Molecular Formula: C₁₅H₂₃NO₄S
• Molecular Weight: 313.418
• Mol file: 808148-14-3.mol

Synonyms:N-benzyl N-(tert-butoxycarbonyl) iso-propylsulfonamide

Chemical Property of N-benzyl N-(tert-butoxycarbonyl) iso-propylsulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl N-(tert-butoxycarbonyl) iso-propylsulfonamide

There total 4 articles about N-benzyl N-(tert-butoxycarbonyl) iso-propylsulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

di-tert-butyl dicarbonate (24424-99-5) + N-benzyl-propane-2-sulfonamide (149944-33-2) → N-benzyl N-(tert-butoxycarbonyl) iso-propylsulfonamide (808148-14-3)

Guidance literature:

With dmap; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tetlet.2004.09.118

Reference yield:

N-benzyl-N-(benzyloxycarbonyl) iso-propylsulfonamide (852459-56-4) → N-benzyl N-(tert-butoxycarbonyl) iso-propylsulfonamide (808148-14-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / hydrogen / Pearlman's catalyst / ethanol / 760.05 Torr

2: 97 percent / DMAP / tetrahydrofuran / 20 °C

With dmap; hydrogen; palladium dihydroxide; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tetlet.2004.09.118

Reference yield:

N-benzylethane-1-sulfonamide (120344-44-7) → N-benzyl N-(tert-butoxycarbonyl) iso-propylsulfonamide (808148-14-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: butyl lithium / tetrahydrofuran / 0.08 h / -50 °C

1.2: 95 percent / tetrahydrofuran / 0.33 h / -50 °C

2.1: 97 percent / DMAP / tetrahydrofuran / 20 °C

With dmap; n-butyllithium; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2004.09.118

upstream raw materials:

di-tert-butyl dicarbonate

N-benzyl-propane-2-sulfonamide

N-benzylethane-1-sulfonamide

benzylamine

Refernces