(S)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-{[(R)-1-(2,3-dihydro-benzo[1,4]dioxin-2-yl)methyl]-methyl-amino}-ethyl) ester 5-methyl ester

Base Information

• Chemical Name: (S)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-{[(R)-1-(2,3-dihydro-benzo[1,4]dioxin-2-yl)methyl]-methyl-amino}-ethyl) ester 5-methyl ester
• CAS No.: 119746-72-4
• Molecular Formula: C₂₈H₃₁N₃O₈
• Molecular Weight: 537.569
• Mol file: 119746-72-4.mol

Synonyms:(S)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-{[(R)-1-(2,3-dihydro-benzo[1,4]dioxin-2-yl)methyl]-methyl-amino}-ethyl) ester 5-methyl ester

Chemical Property of (S)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-{[(R)-1-(2,3-dihydro-benzo[1,4]dioxin-2-yl)methyl]-methyl-amino}-ethyl) ester 5-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-{[(R)-1-(2,3-dihydro-benzo[1,4]dioxin-2-yl)methyl]-methyl-amino}-ethyl) ester 5-methyl ester

There total 4 articles about (S)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-{[(R)-1-(2,3-dihydro-benzo[1,4]dioxin-2-yl)methyl]-methyl-amino}-ethyl) ester 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(R)-5-(methoxycarbonyl)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (76093-33-9) + (2R)-2-amino>ethanol (119816-27-2) → (S)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-{[(R)-1-(2,3-dihydro-benzo[1,4]dioxin-2-yl)methyl]-methyl-amino}-ethyl) ester 5-methyl ester (119746-72-4)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 75 ℃; for 48h;

DOI:10.1021/jm00126a042

Reference yield:

(R)-2-hydroxymethyl-1,4-benzodioxane (62501-72-8) → (S)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-{[(R)-1-(2,3-dihydro-benzo[1,4]dioxin-2-yl)methyl]-methyl-amino}-ethyl) ester 5-methyl ester (119746-72-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / SOCl₂, pyridine / 3 h / 100 °C

2: ethanol / 120 °C

3: 52 percent / dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / dimethylformamide / 48 h / 75 °C

With pyridine; dmap; thionyl chloride; dicyclohexyl-carbodiimide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00126a042

Reference yield:

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → (S)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-{[(R)-1-(2,3-dihydro-benzo[1,4]dioxin-2-yl)methyl]-methyl-amino}-ethyl) ester 5-methyl ester (119746-72-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, oil, r.t., 30 min, 2.) r.t., 10 h

2: 70 percent / SOCl₂, pyridine / 3 h / 100 °C

3: ethanol / 120 °C

4: 52 percent / dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / dimethylformamide / 48 h / 75 °C

With pyridine; dmap; thionyl chloride; sodium hydride; dicyclohexyl-carbodiimide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00126a042

upstream raw materials:

(R)-5-(methoxycarbonyl)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

(2R)-2-amino>ethanol

(R)-2-hydroxymethyl-1,4-benzodioxane

benzene-1,2-diol