N-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-1-dimethylcarbamoylmethyl-5,6-dimethyl-1H-indole-3-carboxamide

Base Information

Chemical Name:N-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-1-dimethylcarbamoylmethyl-5,6-dimethyl-1H-indole-3-carboxamide
CAS No.:1404535-55-2
Molecular Formula:C₂₉H₃₃N₅O₃
Molecular Weight:499.613
Hs Code.:

Synonyms:N-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-1-dimethylcarbamoylmethyl-5,6-dimethyl-1H-indole-3-carboxamide

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Chemical Property of N-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-1-dimethylcarbamoylmethyl-5,6-dimethyl-1H-indole-3-carboxamide

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Technology Process of N-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-1-dimethylcarbamoylmethyl-5,6-dimethyl-1H-indole-3-carboxamide

There total 25 articles about N-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-1-dimethylcarbamoylmethyl-5,6-dimethyl-1H-indole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1404529-46-9
{3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5,6-dimethyl-indol-1-yl}acetic acid

: 506-59-2
N,N-dimethylammonium chloride

: 1404535-55-2
N-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-1-dimethylcarbamoylmethyl-5,6-dimethyl-1H-indole-3-carboxamide

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm500588w

Reference yield:

: 1404532-72-4
{3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5,6-dimethyl-indol-1-yl}acetic acid methyl ester

: 1404535-55-2
N-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-1-dimethylcarbamoylmethyl-5,6-dimethyl-1H-indole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / methanol / 20 °C

2: triethylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 20 °C

With water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1021/jm500588w

Reference yield:

: 99-51-4,34527-23-6,156617-88-8
4-nitro-o-xylene

: 1404535-55-2
N-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-1-dimethylcarbamoylmethyl-5,6-dimethyl-1H-indole-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: palladium 10% on activated carbon; hydrazine hydrate / cyclohexane / 1 h / 0 - 10 °C / Inert atmosphere

1.2: 2 h / 10 °C

2.1: potassium carbonate; methanol / 20 °C

3.1: dmap; sodium hydroxide / tetrahydrofuran / 3 h / 0 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: palladium 10% on activated carbon; ammonium formate / methanol / 12 h / Inert atmosphere; Reflux

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / 1,2-dichloro-ethane / 20 °C

7.1: sodium hydroxide; water / methanol / 20 °C

8.1: triethylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 20 °C

With methanol; dmap; palladium 10% on activated carbon; water; ammonium formate; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm500588w