(+)-(1'S,2'S,2S,3R)-2-benzyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-3-phenylpentanamide

Base Information

Chemical Name:(+)-(1'S,2'S,2S,3R)-2-benzyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-3-phenylpentanamide
CAS No.:897920-49-9
Molecular Formula:C₂₈H₃₃NO₂
Molecular Weight:415.576
Hs Code.:

Synonyms:(+)-(1'S,2'S,2S,3R)-2-benzyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-3-phenylpentanamide

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Chemical Property of (+)-(1'S,2'S,2S,3R)-2-benzyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-3-phenylpentanamide

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Technology Process of (+)-(1'S,2'S,2S,3R)-2-benzyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-3-phenylpentanamide

There total 2 articles about (+)-(1'S,2'S,2S,3R)-2-benzyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-3-phenylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 100-39-0
benzyl bromide

: 591-51-5
phenyllithium

: 678991-33-8
E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pent-2-enamide

: 897920-49-9
(+)-(1'S,2'S,2S,3R)-2-benzyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-3-phenylpentanamide

Guidance literature:: phenyllithium; E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pent-2-enamide; With lithium chloride; In tetrahydrofuran; dibutyl ether; at -105 ℃;

benzyl bromide; In tetrahydrofuran; dibutyl ether; at 0 ℃; for 5h;
DOI:10.1021/ol060720w

Reference yield: 67.0%

: 591-51-5
phenyllithium

: 678991-33-8
E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pent-2-enamide

: 897920-49-9
(+)-(1'S,2'S,2S,3R)-2-benzyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-3-phenylpentanamide

Guidance literature:: phenyllithium; E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pent-2-enamide; With lithium chloride; In tetrahydrofuran; dibutyl ether; at -105 ℃; for 0.5h;

BnX; With lithium chloride; In tetrahydrofuran; dibutyl ether; at 0 ℃; for 5h;
DOI:10.1021/jo061205e

Reference yield:

: 897920-49-9
(+)-(1'S,2'S,2S,3R)-2-benzyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-3-phenylpentanamide

: (-)-(2S,3R)-2-benzyl-3-phenylpentan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: dioxane / 12 h / Heating

2: LiAlH₄ / tetrahydrofuran / 3 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jo061205e