1-(4-chlorophenyl)-3-hydroxy-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

Base Information

• Chemical Name: 1-(4-chlorophenyl)-3-hydroxy-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
• CAS No.: 53661-30-6
• Molecular Formula: C₁₆H₁₃ClN₂O
• Molecular Weight: 284.745
• Mol file: 53661-30-6.mol

Synonyms:1-(4-chlorophenyl)-3-hydroxy-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

Chemical Property of 1-(4-chlorophenyl)-3-hydroxy-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chlorophenyl)-3-hydroxy-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

There total 6 articles about 1-(4-chlorophenyl)-3-hydroxy-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

cyanoacetic acid amide (107-91-5) + 2-(4'-chloro)benzoylcyclohexanone (38968-76-2) → 1-(4-chlorophenyl)-3-hydroxy-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile (53661-30-6)

Guidance literature:

With diethylamine; In ethanol; at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2011.11.020

Reference yield:

1-(4-Chloro-phenyl)-3-thioxo-2,3,5,6,7,8-hexahydro-isoquinoline-4-carbonitrile (129340-02-9) → 1-(4-Chloro-phenyl)-3-oxo-2,3,5,6,7,8-hexahydro-isoquinoline-4-carbonitrile (53661-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / Cl₂ / CHCl₃ / 2 h / Ambient temperature

2: 50 percent / conc. HCl / ethanol / 2 h / Heating

With hydrogenchloride; chlorine; In ethanol; chloroform;

DOI:10.1246/bcsj.65.2241

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(4-chlorophenyl)-3-hydroxy-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile (53661-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: piperidine / benzene / Reflux

1.2: 24 h / Reflux

1.3: 2 h / Reflux

2.1: diethylamine / ethanol / 24 h / 20 °C

With piperidine; diethylamine; In ethanol; benzene; 1.1: Stork acylation / 1.2: Stork acylation / 1.3: Stork acylation;

DOI:10.1016/j.ejmech.2011.11.020

upstream raw materials:

cyclohexanone

4-chloro-benzoyl chloride

cyanoacetic acid amide

2-(4'-chloro)benzoylcyclohexanone

Downstream raw materials:

3-chloro-1-(4-chlorophenyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

5-(4-chlorophenyl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]isoquinolin-1-amine