3'-O-(tert-butyldimethylsilyl)-5'-O-pixyl-5'-(S)-C-(4-(trimethylsilyl)-1,2,3-triazol-1-yl)methylthymidine

Base Information

• Chemical Name: 3'-O-(tert-butyldimethylsilyl)-5'-O-pixyl-5'-(S)-C-(4-(trimethylsilyl)-1,2,3-triazol-1-yl)methylthymidine
• CAS No.: 1260530-57-1
• Molecular Formula: C₄₁H₅₁N₅O₆Si₂
• Molecular Weight: 766.057

Synonyms:3'-O-(tert-butyldimethylsilyl)-5'-O-pixyl-5'-(S)-C-(4-(trimethylsilyl)-1,2,3-triazol-1-yl)methylthymidine

Chemical Property of 3'-O-(tert-butyldimethylsilyl)-5'-O-pixyl-5'-(S)-C-(4-(trimethylsilyl)-1,2,3-triazol-1-yl)methylthymidine

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Technology Process of 3'-O-(tert-butyldimethylsilyl)-5'-O-pixyl-5'-(S)-C-(4-(trimethylsilyl)-1,2,3-triazol-1-yl)methylthymidine

There total 1 articles about 3'-O-(tert-butyldimethylsilyl)-5'-O-pixyl-5'-(S)-C-(4-(trimethylsilyl)-1,2,3-triazol-1-yl)methylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5'-(S)-C-(azidomethyl)-3'-O-(tert-butyldimethylsilyl)-5'-O-pixylthymidine (1260530-50-4) + trimethylsilylacetylene (1066-54-2) → 3'-O-(tert-butyldimethylsilyl)-5'-O-pixyl-5'-(S)-C-(4-(trimethylsilyl)-1,2,3-triazol-1-yl)methylthymidine (1260530-57-1)

Guidance literature:

With pyridine; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 19h;

DOI:10.1002/chem.201001253

Reference yield: 94.0%

3'-O-(tert-butyldimethylsilyl)-5'-O-pixyl-5'-(S)-C-(4-(trimethylsilyl)-1,2,3-triazol-1-yl)methylthymidine (1260530-57-1) → 5'-O-pixyl-5'-(S)-C-(1,2,3-triazol-1-yl)methylthymidine (1260530-58-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 55h; Inert atmosphere;

DOI:10.1002/chem.201001253

upstream raw materials:

5'-(S)-C-(azidomethyl)-3'-O-(tert-butyldimethylsilyl)-5'-O-pixylthymidine

trimethylsilylacetylene

Downstream raw materials:

5'-O-pixyl-5'-(S)-C-(1,2,3-triazol-1-yl)methylthymidine

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