ethyl Z-2-fluoro-3-[3'-(adamantan-1-yl)-4'-tert-butylsilyloxybiphenyl-4-yl]acrylate

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Chemical Name:ethyl Z-2-fluoro-3-[3'-(adamantan-1-yl)-4'-tert-butylsilyloxybiphenyl-4-yl]acrylate
CAS No.:862650-93-9
Molecular Formula:C₃₃H₄₃FO₃Si
Molecular Weight:534.787
Hs Code.:

Synonyms:ethyl Z-2-fluoro-3-[3'-(adamantan-1-yl)-4'-tert-butylsilyloxybiphenyl-4-yl]acrylate

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Chemical Property of ethyl Z-2-fluoro-3-[3'-(adamantan-1-yl)-4'-tert-butylsilyloxybiphenyl-4-yl]acrylate

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Technology Process of ethyl Z-2-fluoro-3-[3'-(adamantan-1-yl)-4'-tert-butylsilyloxybiphenyl-4-yl]acrylate

There total 4 articles about ethyl Z-2-fluoro-3-[3'-(adamantan-1-yl)-4'-tert-butylsilyloxybiphenyl-4-yl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 459423-14-4
3’-(adamantan-1-yl)-4’-tert-butyldimethylsilyloxybiphenyl-4-aldehyde

: 2356-16-3
ethyl(diethylphosphono)(fluoro)acetate

: 862650-93-9
ethyl Z-2-fluoro-3-[3'-(adamantan-1-yl)-4'-tert-butylsilyloxybiphenyl-4-yl]acrylate

Guidance literature:: ethyl(diethylphosphono)(fluoro)acetate; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 1h;

3’-(adamantan-1-yl)-4’-tert-butyldimethylsilyloxybiphenyl-4-aldehyde; In tetrahydrofuran; hexane; for 8h; Heating;
DOI:10.1021/jm049440h

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 862650-93-9
ethyl Z-2-fluoro-3-[3'-(adamantan-1-yl)-4'-tert-butylsilyloxybiphenyl-4-yl]acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N; DMAP / dimethylformamide

2.1: 1.09 g / aq. Na₂CO₃; Pd(PPh₃)4 / toluene; ethanol / 2 h / Heating

3.1: n-BuLi / tetrahydrofuran; hexane / 1 h / 0 °C

3.2: 16 percent / tetrahydrofuran; hexane / 8 h / Heating

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; triethylamine; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide; toluene; 2.1: Suzuki coupling / 3.2: Wittig-Horner reaction;
DOI:10.1021/jm049440h

Reference yield:

: 104224-68-2
2-(1-adamantyl)-4-bromophenol

: 862650-93-9
ethyl Z-2-fluoro-3-[3'-(adamantan-1-yl)-4'-tert-butylsilyloxybiphenyl-4-yl]acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N; DMAP / dimethylformamide

2.1: 1.09 g / aq. Na₂CO₃; Pd(PPh₃)4 / toluene; ethanol / 2 h / Heating

3.1: n-BuLi / tetrahydrofuran; hexane / 1 h / 0 °C

3.2: 16 percent / tetrahydrofuran; hexane / 8 h / Heating

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; triethylamine; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide; toluene; 2.1: Suzuki coupling / 3.2: Wittig-Horner reaction;
DOI:10.1021/jm049440h