(R)-2-Benzyloxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-propionic acid

Base Information

• Chemical Name: (R)-2-Benzyloxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-propionic acid
• CAS No.: 903881-41-4
• Molecular Formula: C₁₈H₂₇N₃O₈S
• Molecular Weight: 445.494
• Mol file: 903881-41-4.mol

Synonyms:(R)-2-Benzyloxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-propionic acid

Chemical Property of (R)-2-Benzyloxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-Benzyloxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-propionic acid

There total 2 articles about (R)-2-Benzyloxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-benzyloxycarbonylamino-3-chlorosulfonylpropionic acid benzyl ester (64957-08-0) + N-(tert-butyloxycarbonyl)-1,2-ethanediamine hydrochloride (79513-35-2,117083-06-4) → (R)-2-Benzyloxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-propionic acid (903881-41-4) + (S)-2-Benzyloxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-propionic acid benzyl ester

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (R)-2-Benzyloxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-propionic acid (903881-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / 1N NaOH (phenolphthalein) / H₂O; propan-2-ol / 24 h / Ambient temperature

2: 91 percent / DIPEA / dimethylformamide / 1 h / 0 °C

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; isopropyl alcohol;

upstream raw materials:

2-benzyloxycarbonylamino-3-chlorosulfonylpropionic acid benzyl ester

N-(tert-butyloxycarbonyl)-1,2-ethanediamine hydrochloride

di-tert-butyl dicarbonate