1-{4-[5-methyl-6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-cyclobutylamine

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Chemical Name:1-{4-[5-methyl-6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-cyclobutylamine
CAS No.:1439396-95-8
Molecular Formula:C₂₆H₂₄N₆
Molecular Weight:420.517
Hs Code.:

Synonyms:1-{4-[5-methyl-6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-cyclobutylamine

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Chemical Property of 1-{4-[5-methyl-6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-cyclobutylamine

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Technology Process of 1-{4-[5-methyl-6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-cyclobutylamine

There total 4 articles about 1-{4-[5-methyl-6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-cyclobutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1439396-97-0
(1-{ 4-[5-methyl-6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester

: 1439396-95-8
1-{4-[5-methyl-6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-cyclobutylamine

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1439394-87-2
tert-butyl 1-(4-(2-chloro-5-iodopyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

: 1439396-95-8
1-{4-[5-methyl-6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-cyclobutylamine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; lithium chloride; triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; 1,2-dimethoxyethane / 100 °C / Inert atmosphere

3: hydrogenchloride / ethyl acetate / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; potassium carbonate; caesium carbonate; triphenylphosphine; lithium chloride; In 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1439396-93-6
{1-[4-(2-chloro-5-methyl-6-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

: 1439396-95-8
1-{4-[5-methyl-6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-cyclobutylamine

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; 1,2-dimethoxyethane / 100 °C / Inert atmosphere

2: hydrogenchloride / ethyl acetate / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,2-dimethoxyethane; water; ethyl acetate;