5-{2-[(1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]-1-hydroxyethyl}benzene-1,3-diol

Base Information

Chemical Name:5-{2-[(1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]-1-hydroxyethyl}benzene-1,3-diol
CAS No.:1619984-04-1
Molecular Formula:C₂₂H₃₄O₃
Molecular Weight:346.51
Hs Code.:

Synonyms:5-{2-[(1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]-1-hydroxyethyl}benzene-1,3-diol

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Chemical Property of 5-{2-[(1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]-1-hydroxyethyl}benzene-1,3-diol

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Technology Process of 5-{2-[(1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]-1-hydroxyethyl}benzene-1,3-diol

There total 6 articles about 5-{2-[(1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]-1-hydroxyethyl}benzene-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1619983-06-0
2-[(1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]-1-(3,5-dihydroxyphenyl)ethan-1-one

: 1619984-04-1
5-{2-[(1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]-1-hydroxyethyl}benzene-1,3-diol

: 1619983-15-1
5-{2-[(1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]-1-hydroxyethyl}benzene-1,3-diol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Overall yield = 79 %; Overall yield = 375 mg; Inert atmosphere;

Reference yield:

: C₂₄H₃₅ClO₃

: 1619984-04-1
5-{2-[(1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]-1-hydroxyethyl}benzene-1,3-diol

: 1619983-15-1
5-{2-[(1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]-1-hydroxyethyl}benzene-1,3-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 2327.23 Torr

1.2: 1.5 h / 0 - 20 °C / Inert atmosphere

1.3: 1.5 h / 0 - 60 °C

2.1: boron tribromide / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere

2.2: 0.58 h / 85 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; boron tribromide; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: 1619983-04-8
2-[(1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]-1-(3,5-dimethoxyphenyl)ethan-1-one

: 1619984-04-1
5-{2-[(1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]-1-hydroxyethyl}benzene-1,3-diol

: 1619983-15-1
5-{2-[(1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]-1-hydroxyethyl}benzene-1,3-diol

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron tribromide / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere

1.2: 0.58 h / 85 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; boron tribromide; In tetrahydrofuran; dichloromethane;