(S)-Hydroxy-phenyl-acetic acid (R)-1-bromomethyl-5-trityloxy-pentyl ester

Base Information

Chemical Name:(S)-Hydroxy-phenyl-acetic acid (R)-1-bromomethyl-5-trityloxy-pentyl ester
CAS No.:924654-74-0
Molecular Formula:C₃₃H₃₃BrO₄
Molecular Weight:573.527
Hs Code.:

Synonyms:(S)-Hydroxy-phenyl-acetic acid (R)-1-bromomethyl-5-trityloxy-pentyl ester

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Chemical Property of (S)-Hydroxy-phenyl-acetic acid (R)-1-bromomethyl-5-trityloxy-pentyl ester

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Technology Process of (S)-Hydroxy-phenyl-acetic acid (R)-1-bromomethyl-5-trityloxy-pentyl ester

There total 1 articles about (S)-Hydroxy-phenyl-acetic acid (R)-1-bromomethyl-5-trityloxy-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 17199-29-0
(S)-Mandelic acid

: 185999-03-5
6-(trityloxy)hex-1-en

: 924654-74-0
(S)-Hydroxy-phenyl-acetic acid (R)-1-bromomethyl-5-trityloxy-pentyl ester

: (S)-Hydroxy-phenyl-acetic acid (S)-1-bromomethyl-5-trityloxy-pentyl ester

Guidance literature:: With 2,6-dimethylpyridine; N-Bromosuccinimide; In dichloromethane;
DOI:10.1021/jo061818r

Reference yield: 86.0%

: 924654-74-0
(S)-Hydroxy-phenyl-acetic acid (R)-1-bromomethyl-5-trityloxy-pentyl ester

: 150-76-5
4-methoxy-phenol

: 924654-86-4
(R)-1-(4-Methoxy-phenoxy)-6-trityloxy-hexan-2-ol

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; at 95 ℃; for 16h;
DOI:10.1021/jo061818r

Reference yield:

: 924654-74-0
(S)-Hydroxy-phenyl-acetic acid (R)-1-bromomethyl-5-trityloxy-pentyl ester

: (S)-2-(4-Trityloxy-butyl)-oxirane

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / KOH / tetrahydrofuran / 16 h / 95 °C

2: 85 percent / 4-(dimethylamino)pyridine; triethylamine / CH₂Cl₂

3: ammonium cerium(IV) nitrate / tetrahydrofuran; H₂O / 0.5 h / -5 °C

4: K₂CO₃ / methanol / 0.33 h

With dmap; potassium hydroxide; ammonium cerium(IV) nitrate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo061818r