Technology Process of (3aS,7aS)-3a-(3,4-Dimethoxy-phenyl)-hexahydro-benzofuran-2-one
There total 12 articles about (3aS,7aS)-3a-(3,4-Dimethoxy-phenyl)-hexahydro-benzofuran-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
for 1h;
Ambient temperature;
DOI:10.1016/S0040-4039(98)01689-X
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 90 percent / AD-mix-α, K2CO3, K3Fe(CN)6, MeSO2NH2 / 2-methyl-propan-2-ol; H2O / 48 h / Ambient temperature
2: 96 percent / Et3N, DMAP / CH2Cl2 / 24 h / Ambient temperature
3: 98 percent / Et3NSO2NCO2Me / toluene / 1 h / 50 °C
4: 98 percent / LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature
5: 98 percent / NBS / diethyl ether / 24 h / 0 °C / to RT
6: 87 percent / Bu3SnCl, AIBN, NaBH4 / 2-methyl-propan-2-ol / 6 h / Heating
7: 93 percent / mCPBA, BF3*OEt2 / CH2Cl2 / 1 h / Ambient temperature
With
dmap; sodium tetrahydroborate; AD-mix-α; N-Bromosuccinimide; lithium aluminium tetrahydride; Burgess Reagent; 2,2'-azobis(isobutyronitrile); methanesulfonamide; boron trifluoride diethyl etherate; tributyltin chloride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; potassium hexacyanoferrate(III);
In
tetrahydrofuran; diethyl ether; dichloromethane; water; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4039(98)01689-X
- Guidance literature:
-
Multi-step reaction with 4 steps
2: 98 percent / NBS / diethyl ether / 24 h / 0 °C / to RT
3: 87 percent / Bu3SnCl, AIBN, NaBH4 / 2-methyl-propan-2-ol / 6 h / Heating
4: 93 percent / mCPBA, BF3*OEt2 / CH2Cl2 / 1 h / Ambient temperature
With
sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; tributyltin chloride; 3-chloro-benzenecarboperoxoic acid;
In
diethyl ether; dichloromethane; tert-butyl alcohol;
DOI:10.1016/S0040-4039(98)01689-X
