3-{2-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-phenyl}-prop-2-yn-1-ol

Base Information

• Chemical Name: 3-{2-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-phenyl}-prop-2-yn-1-ol
• CAS No.: 128970-11-6
• Molecular Formula: C₁₉H₂₆O₂Si
• Molecular Weight: 314.5

Synonyms:3-{2-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-phenyl}-prop-2-yn-1-ol

Chemical Property of 3-{2-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-phenyl}-prop-2-yn-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{2-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-phenyl}-prop-2-yn-1-ol

There total 2 articles about 3-{2-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-phenyl}-prop-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

[4-(2-Bromo-phenyl)-but-3-ynyloxy]-tert-butyl-dimethyl-silane (128970-10-5) + propargyl alcohol (107-19-7) → 3-{2-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-phenyl}-prop-2-yn-1-ol (128970-11-6)

Guidance literature:

With triethylamine; copper(I) bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; for 3h; Heating;

DOI:10.1016/S0040-4039(00)94366-1

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 3-{2-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-phenyl}-prop-2-yn-1-ol (128970-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent

2: 75 percent / NEt₃ / Pd(PPh₃)4, Cu₂Br₂ / 3 h / Heating

With triethylamine; copper(I) bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾;

DOI:10.1016/S0040-4039(00)94366-1

Reference yield: 95.0%

3-{2-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-phenyl}-prop-2-yn-1-ol (128970-11-6) → {4-[2-(3-Bromo-prop-1-ynyl)-phenyl]-but-3-ynyloxy}-tert-butyl-dimethyl-silane (128970-12-7)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In acetonitrile; at 0 ℃; for 0.25h;

DOI:10.1016/S0040-4039(00)94366-1

upstream raw materials:

[4-(2-Bromo-phenyl)-but-3-ynyloxy]-tert-butyl-dimethyl-silane

propargyl alcohol

tert-butyldimethylsilyl chloride

Downstream raw materials:

{4-[2-(3-Bromo-prop-1-ynyl)-phenyl]-but-3-ynyloxy}-tert-butyl-dimethyl-silane

Methanesulfonic acid 3-{2-[4-(tert-butyl-dimethyl-silanyloxy)-but-1-ynyl]-phenyl}-prop-2-ynyl ester

4-[2-(3-Bromo-prop-1-ynyl)-phenyl]-but-3-yn-1-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 128970-11-6 3-{2-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-phenyl}-prop-2-yn-1-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send