(S)-3-[(S)-2-methylamino-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester trifluoroacetate

Base Information

Chemical Name:(S)-3-[(S)-2-methylamino-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester trifluoroacetate
CAS No.:1380182-93-3
Molecular Formula:C₂HF₃O₂*C₁₉H₂₇F₃N₂O₃
Molecular Weight:502.454
Hs Code.:

Synonyms:(S)-3-[(S)-2-methylamino-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester trifluoroacetate

Suppliers and Price of (S)-3-[(S)-2-methylamino-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-3-[(S)-2-methylamino-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-[(S)-2-methylamino-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester trifluoroacetate

There total 6 articles about (S)-3-[(S)-2-methylamino-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 815-06-5
N-methyl-2,2,2-trifluoroacetamide

: C₂₅H₃₀F₃NO₆S

: 76-05-1
trifluoroacetic acid

: 1380182-93-3
(S)-3-[(S)-2-methylamino-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester trifluoroacetate

Guidance literature:: N-methyl-2,2,2-trifluoroacetamide; With potassium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

C₂₅H₃₀F₃NO₆S; In N,N-dimethyl-formamide; at 60 ℃;

trifluoroacetic acid; In water; acetic acid;

Reference yield:

: 1228312-14-8
(R)-3-vinylpyrrolidine-1-carboxylic acid t-butyl ester

: 1380182-93-3
(S)-3-[(S)-2-methylamino-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dihydrogen peroxide / pyridine-3-carbonitrile; methyltrioxorhenium(VII) / water / 2 h / Cooling with ice

2.1: sodium hydride / 50 °C / Inert atmosphere

2.2: 50 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 3.17 h / 20 - 90 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / methanol / 760.05 Torr

5.1: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 1 h / 0 - 20 °C

6.1: potassium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

6.2: 60 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogen; dihydrogen peroxide; potassium hydride; sodium hydride; pyridine-3-carbonitrile; palladium 10% on activated carbon; methyltrioxorhenium(VII); In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1262116-18-6
(S)-(S)-3-oxiranylpyrrolidine-1-carboxylic acid t-butyl ester

: 1380182-93-3
(S)-3-[(S)-2-methylamino-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / 50 °C / Inert atmosphere

1.2: 50 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 3.17 h / 20 - 90 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 760.05 Torr

4.1: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 1 h / 0 - 20 °C

5.1: potassium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

5.2: 60 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogen; potassium hydride; sodium hydride; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;