815-06-5

Basic information

• Product Name: N-Methyl-2,2,2-trifluoroacetamide
• Synonyms: N-METHYL-2,2,2-TRIFLUOROACETAMIDE;TIMTEC-BB SBB008211;2,2,2-trifluoro-n-methyl-acetamid;N-Methyltrifluoroacetamide,98%;N-Methyl-2,2,2-trifluoroacetamide 98%;N-metnyl-2,2,2-trifluoroacetamide;N-Methyl-2,2,2-trifluoroacetamide, 98+%;N-Methyl-2,2,2-trifl
• CAS NO: 815-06-5
• Molecular Formula: C₃H₄F₃NO
• Molecular Weight: 127.07
• EINECS: 212-417-7
• Product Categories: Amides;Carbonyl Compounds;Organic Building Blocks;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;C2 to C7
• Mol File: 815-06-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 49-51 °C(lit.)
• Boiling Point: 156-157 °C(lit.)
• Flash Point: 165 °F
• Appearance: white crystals or crystalline powder
• Density: 1.3215 (estimate)
• Vapor Pressure: 2.88mmHg at 25°C
• Refractive Index: 1.322
• Storage Temp.: Store below +30°C.
• PKA: 11.54±0.46(Predicted)
• Sensitive: Hygroscopic
• BRN: 1703392
• CAS DataBase Reference: N-Methyl-2,2,2-trifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-2,2,2-trifluoroacetamide(815-06-5)
• EPA Substance Registry System: N-Methyl-2,2,2-trifluoroacetamide(815-06-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• RIDADR: UN 1325 4.1/PG 2
• WGK Germany: 3
• F: 3-10-21
• TSCA: T
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 815-06-5(Hazardous Substances Data)

Usage

Chemical Properties

WHITE CRYSTALS OR CRYSTALLINE POWDER

General Description

The high-resolution proton and fluorine resonance spectra of N-methyltrifluoroacetamide in tetrahydrofuran and acetone was studied.

InChI:InChI=1/C3H4F3NO/c1-7-2(8)3(4,5)6/h1H3,(H,7,8)

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 74-89-5 methylamine 
• 407-25-0 trifluoroacetic anhydride 
• 78162-73-9 N-chloro-N-methyltrifluoroacetamide 
• 354-38-1 2,2,2-trifluoroacetamide 
• 109317-75-1 4-trifluoroacetyl-2,3-dihydrofuran 
• 152421-76-6 1-trifluoroacetyl-3-trifluoromethyl-3a,8b-dihydro-1H,4H-indeno<1,2-c>pyrazole 
• 110-83-8 cyclohexene 
• 143017-65-6 C₁₁H₁₆FNOSi 
• 100-46-9 benzylamine 
• 143017-66-7 N-Benzyl-N-(trimethylsilyl)acetamide 
• 23728-68-9 N-Methyl-N-(trimethylsilyl)benzamide 
• 23138-72-9 N-trimethylsilyle du N-ethylacetamide 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 2730-67-8 N-methyl-N-(2,2,2-trifluoroethyl)amine 
• 685-27-8 2,2,2-trifluoro-N-methyl-N-(2,2,2-trifluoroacetyl)acetamide 
• 77377-52-7 N-methyl-N-tert-butyldimethylsilyl-1,1,1-trifluoroacetamide 
• 24589-78-4 N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide 
• 75-89-8 2,2,2-trifluoroethanol 
• 1380182-93-3 (S)-3-[(S)-2-methylamino-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester trifluoroacetate 
• 383-65-3 N-allyltrifluoroacetamide 
• 1173908-58-1 bis(N-methyl-2,2,2-trifluoroacetamido)methylphenylsilane 
• 898560-75-3 N-(diphenylphosphino)-N-methyltrifluoroacetamide 
• 261718-55-2 N-[2-[4-[3,17β-bis[tetrahydro(2H)-2-pyranyloxy]estra-1,3,5(10)-trien-11β-yl]phenoxy]ethyl]-N-methyltrifluoroacetamide 
• 556-61-6 methyl thioisocyanate 
• 68464-36-8 N-benzyl-2,2,2,-trifluoro-N-methylacetamide 
• 2730-52-1 N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride 

Relevant articles and documents

Method of Synthesizing of N-methyl-N-trimethylsilyl trifluoroacetamide, N-methyl-N-trimethylsilyl trifluoroacetamide synthesized thereby and an electrolyte for lithium secondary battery including the same

The present invention relates to a synthesis method of N-methyl-N-trimethylsilyl trifluoroacetamide (MSTFA), MSTFA synthesized thereby and an electrolyte for a lithium secondary battery including the same. The present invention comprises the steps of: preparing N-methyltrifluoroacetamide by using ethyltrifluoroacetate and methylamine; and obtaining MSTFA by separating and removing a precipitate from a reaction mixture obtained by introducing trimethylsilyl chloride to a mixture of N-methyltrifluoroacetamide and triethylamine. According to the present invention, since BSA (N,O-bis(trimethylsilyl)acetamide) is not used, it is relatively easy to remove a starting material and a side reaction material which are not reacted by fractional distillation. Therefore, it is possible to obtain a high-purity MSTFA of 99.0% or more and if the high-purity MSTFA of 99.0% or more is used as an additive of an electrolyte for a lithium secondary battery, it is possible to improve lifespan characteristics of a lithium secondary battery.COPYRIGHT KIPO 2015

Novel compounds and methods for synthesis and therapy

Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

N-Substituted trifluoroacetimidoyl halides: Synthesis and properties

N-Substituted trifluoroacetimidoyl halides in ionic-type transformations readily undergo nucleophilic substitution and dehydrofluorination rather than 1,3-dehydrohalogenation to give nitrile ylides.