methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetate

Base Information

Chemical Name:methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetate
CAS No.:1403382-05-7
Molecular Formula:C₃₃H₃₃NO₄
Molecular Weight:507.629
Hs Code.:

Synonyms:methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetate

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Chemical Property of methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetate

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Technology Process of methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetate

There total 11 articles about methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 939430-30-5
3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine

: 1403381-74-7
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[(trifluoromethane)sulfonyloxy]phenyl]acetate

: 1403382-05-7
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 80 ℃; for 1h; irradiated 200W;

Reference yield:

: 52085-14-0
4-benzoxy-salicylaldehyde

: 1403382-05-7
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetate

Guidance literature:: Multi-step reaction with 8 steps

1: dmap; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / Reflux

3: zinc(II) iodide / dichloromethane / 0 - 20 °C / Inert atmosphere

4: hydrogenchloride / 240 h

5: perchloric acid / 2 h / -10 - 0 °C

6: hydrogen / palladium on activated charcoal / isopropyl alcohol

7: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

8: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 80 °C / irradiated 200W

With hydrogenchloride; dmap; perchloric acid; hydrogen; sodium carbonate; potassium carbonate; triethylamine; zinc(II) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 63503-60-6
3-chlorophenylboronic acid

: 1403382-05-7
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 80 °C

2: tricyclohexylphosphine; potassium acetate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 1 h / 80 °C / irradiated 200W

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 80 °C / irradiated 200W

With potassium acetate; potassium carbonate; tricyclohexylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; toluene;