2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetic acid

Base Information

Chemical Name:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetic acid
CAS No.:1403381-01-0
Molecular Formula:C₃₂H₃₁NO₄
Molecular Weight:493.602
Hs Code.:

Synonyms:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetic acid

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Chemical Property of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetic acid

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Technology Process of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetic acid

There total 11 articles about 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1403382-05-7
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetate

: 1403381-01-0
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetic acid

Guidance literature:: methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetate; With water; potassium hydroxide; In ethanol; at 95 ℃; for 24h;

With sodium dihydrogenphosphate; In water;

Reference yield:

: 52085-14-0
4-benzoxy-salicylaldehyde

: 1403381-01-0
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1: dmap; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / Reflux

3: zinc(II) iodide / dichloromethane / 0 - 20 °C / Inert atmosphere

4: hydrogenchloride / 240 h

5: perchloric acid / 2 h / -10 - 0 °C

6: hydrogen / palladium on activated charcoal / isopropyl alcohol

7: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

8: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 80 °C / irradiated 200W

9: potassium hydroxide; water / ethanol / 24 h / 95 °C

With hydrogenchloride; dmap; perchloric acid; water; hydrogen; sodium carbonate; potassium carbonate; triethylamine; potassium hydroxide; zinc(II) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 63503-60-6
3-chlorophenylboronic acid

: 1403381-01-0
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-[3-(pyridin-3-yl)phenyl]phenyl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 80 °C

2: tricyclohexylphosphine; potassium acetate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 1 h / 80 °C / irradiated 200W

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 80 °C / irradiated 200W

4: potassium hydroxide; water / ethanol / 24 h / 95 °C

With water; potassium acetate; potassium carbonate; potassium hydroxide; tricyclohexylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; toluene;