7-[(4-chlorophenyl)(1-methylethyl)amino]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one

Base Information

Chemical Name:7-[(4-chlorophenyl)(1-methylethyl)amino]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one
CAS No.:851888-41-0
Molecular Formula:C₁₇H₁₈ClN₃O
Molecular Weight:315.802
Hs Code.:

Synonyms:7-[(4-chlorophenyl)(1-methylethyl)amino]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-[(4-chlorophenyl)(1-methylethyl)amino]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one

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Technology Process of 7-[(4-chlorophenyl)(1-methylethyl)amino]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one

There total 5 articles about 7-[(4-chlorophenyl)(1-methylethyl)amino]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 851888-40-9
4-[(4-chlorophenyl)(1-methylethyl)amino]-1-(4-methoxybenzyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

: 851888-41-0
7-[(4-chlorophenyl)(1-methylethyl)amino]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one

Guidance literature:: With trifluoroacetic acid; at 65 ℃;
DOI:10.1016/j.bmc.2016.08.005

Reference yield:

: 851886-92-5
7-amino-1-methyl-1,3-dihydro-2H-benzimidazol-2-one

: 851888-41-0
7-[(4-chlorophenyl)(1-methylethyl)amino]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: CyJohnPhos; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 22 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 1.67 h / 70 °C

3: sodium hydride; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide; mineral oil / 6 h / 60 °C

4: trifluoroacetic acid / 65 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; trifluoroacetic acid; sodium t-butanolate; CyJohnPhos; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2016.08.005

Reference yield:

: 606-21-3
1-chloro-2,6-dinitrobenzene

: 851888-41-0
7-[(4-chlorophenyl)(1-methylethyl)amino]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: methanol / 3 h / 20 °C

2: hydrogen; palladium on activated charcoal / tetrahydrofuran / 7 h / 20 °C

3: tetrahydrofuran / 24 h / 20 °C

4: CyJohnPhos; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 22 h / Reflux

5: potassium carbonate / N,N-dimethyl-formamide / 1.67 h / 70 °C

6: sodium hydride; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide; mineral oil / 6 h / 60 °C

7: trifluoroacetic acid / 65 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; trifluoroacetic acid; sodium t-butanolate; CyJohnPhos; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2016.08.005