4-[(4-chlorophenyl)(1-methylethyl)amino]-1-(4-methoxybenzyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

Base Information

Chemical Name:4-[(4-chlorophenyl)(1-methylethyl)amino]-1-(4-methoxybenzyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one
CAS No.:851888-40-9
Molecular Formula:C₂₅H₂₆ClN₃O₂
Molecular Weight:435.953
Hs Code.:

Synonyms:4-[(4-chlorophenyl)(1-methylethyl)amino]-1-(4-methoxybenzyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

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Chemical Property of 4-[(4-chlorophenyl)(1-methylethyl)amino]-1-(4-methoxybenzyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

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Technology Process of 4-[(4-chlorophenyl)(1-methylethyl)amino]-1-(4-methoxybenzyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

There total 6 articles about 4-[(4-chlorophenyl)(1-methylethyl)amino]-1-(4-methoxybenzyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 851888-39-6
4-[(4-chlorophenyl)amino]-1-(4-methoxybenzyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

: 75-26-3
isopropyl bromide

: 851888-40-9
4-[(4-chlorophenyl)(1-methylethyl)amino]-1-(4-methoxybenzyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In DMF (N,N-dimethyl-formamide); at 60 ℃; for 6h;

Reference yield:

: 851886-92-5
7-amino-1-methyl-1,3-dihydro-2H-benzimidazol-2-one

: 851888-40-9
4-[(4-chlorophenyl)(1-methylethyl)amino]-1-(4-methoxybenzyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: CyJohnPhos; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 22 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 1.67 h / 70 °C

3: sodium hydride; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide; mineral oil / 6 h / 60 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; sodium t-butanolate; CyJohnPhos; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2016.08.005

Reference yield:

: 606-21-3
1-chloro-2,6-dinitrobenzene

: 851888-40-9
4-[(4-chlorophenyl)(1-methylethyl)amino]-1-(4-methoxybenzyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: methanol / 3 h / 20 °C

2: hydrogen; palladium on activated charcoal / tetrahydrofuran / 7 h / 20 °C

3: tetrahydrofuran / 24 h / 20 °C

4: CyJohnPhos; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 22 h / Reflux

5: potassium carbonate / N,N-dimethyl-formamide / 1.67 h / 70 °C

6: sodium hydride; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide; mineral oil / 6 h / 60 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; sodium t-butanolate; CyJohnPhos; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2016.08.005