3-(benzyl(methyl)amino)-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-ol hydrochloride

Base Information

Chemical Name:3-(benzyl(methyl)amino)-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-ol hydrochloride
CAS No.:1346461-21-9
Molecular Formula:C₂₂H₂₄ClNO₂*ClH
Molecular Weight:406.352
Hs Code.:

Synonyms:3-(benzyl(methyl)amino)-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-ol hydrochloride

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Chemical Property of 3-(benzyl(methyl)amino)-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-ol hydrochloride

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Technology Process of 3-(benzyl(methyl)amino)-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-ol hydrochloride

There total 3 articles about 3-(benzyl(methyl)amino)-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.4%

: 1346596-14-2
C₂₂H₂₂ClNO₂

: 1346461-21-9
3-(benzyl(methyl)amino)-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-ol hydrochloride

Guidance literature:: C₂₂H₂₂ClNO₂; With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h;

With hydrogenchloride; In ethanol; ethyl acetate; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2014.08.045

Reference yield:

: 1200806-20-7
3-chloro-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one

: 1346461-21-9
3-(benzyl(methyl)amino)-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-ol hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

1.2: 1 h / 20 °C

2.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

2.2: 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile;
DOI:10.1016/j.ejmech.2014.08.045

Reference yield:

: 13101-92-3
1-chloro-2-methoxynaphthalene

: 1346461-21-9
3-(benzyl(methyl)amino)-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-ol hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / chloroform / 1 h / 10 - 20 °C

1.2: 2.5 h / 20 °C

2.1: hydrogenchloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

2.2: 1 h / 20 °C

3.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

3.2: 1 h / 20 °C

With hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In methanol; chloroform; acetonitrile; 1.1: |Friedel-Crafts Acylation / 1.2: |Friedel-Crafts Acylation;
DOI:10.1016/j.ejmech.2014.08.045