(-)-1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: (-)-1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 1448701-62-9
• Molecular Formula: C₁₇H₁₈ClNO₂
• Molecular Weight: 303.788
• Mol file: 1448701-62-9.mol

Synonyms:(-)-1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property of (-)-1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

There total 6 articles about (-)-1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (55507-15-8) → (-)-1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (1448701-62-9)

Guidance literature:

1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; With N-Bromosuccinimide; bis(1,5-cyclooctadiene)diiridium(I) dichloride; sodium carbonate; (+)-(R)-[2,3,2',3'-tetrahydro-5,5'-bi(1,4-benzodioxin)-6,6'-diyl]bis(diphenylphosphane); In 1,2-dichloro-ethane; at 20 ℃; for 0.166667h;

With hydrogen; In 1,2-dichloro-ethane; at 30 ℃; for 24h; under 25858.1 Torr;

DOI:10.1021/jacs.5b06659

Reference yield:

6,7-dimethoxy-1-<(para-chloro)phenyl>-3,4-dihydroisoquinoline (76201-90-6) → (-)-1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (1448701-62-9) + (-)-1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:

With formic acid; RuCl[(1R,2R)-p-TsNCH(C6H5)CH-(C6H5)NH2](η6-benzene); triethylamine; In isopropyl alcohol; at 30 ℃; for 16h; Overall yield = 85 %; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201301134

Reference yield:

6,7-dimethoxy-1-<(para-chloro)phenyl>-3,4-dihydroisoquinoline (76201-90-6) → (-)-1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (1448701-62-9)

Guidance literature:

With D-Glucose; NADPH; Reagent/catalyst; enantioselective reaction; Enzymatic reaction;

DOI:10.1021/acscatal.7b02628

upstream raw materials:

6,7-dimethoxy-1-<(para-chloro)phenyl>-3,4-dihydroisoquinoline

1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

N-(3,4-dimethoxyphenethyl)-4-chlorobenzamide

4-chloro-benzoyl chloride