N-(3-acetyl-2-hydroxy-5-methylphenyl)-1H-tetrazole-5-carboxamide methoxime

Base Information

• Chemical Name: N-(3-acetyl-2-hydroxy-5-methylphenyl)-1H-tetrazole-5-carboxamide methoxime
• CAS No.: 70977-62-7
• Molecular Formula: C₁₂H₁₄N₆O₃
• Molecular Weight: 290.282
• Mol file: 70977-62-7.mol

Synonyms:N-(3-acetyl-2-hydroxy-5-methylphenyl)-1H-tetrazole-5-carboxamide methoxime

Chemical Property of N-(3-acetyl-2-hydroxy-5-methylphenyl)-1H-tetrazole-5-carboxamide methoxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-acetyl-2-hydroxy-5-methylphenyl)-1H-tetrazole-5-carboxamide methoxime

There total 7 articles about N-(3-acetyl-2-hydroxy-5-methylphenyl)-1H-tetrazole-5-carboxamide methoxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide (70977-39-8) + N-methoxylamine hydrochloride (593-56-6) → N-(3-acetyl-2-hydroxy-5-methylphenyl)-1H-tetrazole-5-carboxamide methoxime (70977-62-7)

Guidance literature:

With sodium carbonate; In water; at 95 - 100 ℃; for 21h;

DOI:10.1021/jm00154a019

Reference yield:

2-hydroxy-5-methyl-3-nitroacetophenone (66108-30-3) → N-(3-acetyl-2-hydroxy-5-methylphenyl)-1H-tetrazole-5-carboxamide methoxime (70977-62-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 48 percent / H₂ / 5percent Pd/C / ethanol

2: diethyl ether / 1 h / 0 °C

3: 26 percent / NaN₃, AlCl₃ / tetrahydrofuran / 24 h / Heating

4: 63 percent / Na₂CO₃ / H₂O / 21 h / 95 - 100 °C

With aluminium trichloride; sodium azide; hydrogen; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; water;

DOI:10.1021/jm00154a019

Reference yield:

3-acetyl-2-hydroxy-5-methylaniline (70977-71-8) → N-(3-acetyl-2-hydroxy-5-methylphenyl)-1H-tetrazole-5-carboxamide methoxime (70977-62-7)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 1 h / 0 °C

2: 26 percent / NaN₃, AlCl₃ / tetrahydrofuran / 24 h / Heating

3: 63 percent / Na₂CO₃ / H₂O / 21 h / 95 - 100 °C

With aluminium trichloride; sodium azide; sodium carbonate; In tetrahydrofuran; diethyl ether; water;

DOI:10.1021/jm00154a019

upstream raw materials:

1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide

N-methoxylamine hydrochloride

1-benzyl-1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide

1-(4-methoxy-benzyl)-1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide