rhazinilam

Base Information

Chemical Name:rhazinilam
CAS No.:883456-51-7
Molecular Formula:C₁₉H₂₂N₂O
Molecular Weight:294.396
Hs Code.:

Synonyms:rhazinilam

Suppliers and Price of rhazinilam

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rhazinilam

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of rhazinilam

There total 19 articles about rhazinilam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 197218-93-2
10-(carbomethoxy)rhazinilam

: 36193-36-9,52745-52-5,75023-11-9
(±)-rhazinilam

: 883456-51-7
rhazinilam

Guidance literature:: 10-(carbomethoxy)rhazinilam; With sodium hydroxide; In methanol; water; at 50 ℃; for 0.5h;

With hydrogenchloride; In methanol; water; at 50 ℃; for 4h; pH=2; Title compound not separated from byproducts;
DOI:10.1021/ja0629110

Reference yield:

: 197141-94-9
(R)-3-(1-(2-aminophenyl)-8-ethyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoic acid

: 36193-36-9,52745-52-5,75023-11-9
(±)-rhazinilam

: 883456-51-7
rhazinilam

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 3h; Overall yield = 39.2 mg; Inert atmosphere;
DOI:10.1002/anie.201508906

Reference yield:

: (S)-tert-butyl(3-(1-ethyl-2-(2-nitrobenzyl)cyclopent-2-en-1-yl)propoxy)dimethylsilane

: 36193-36-9,52745-52-5,75023-11-9
(±)-rhazinilam

: 883456-51-7
rhazinilam

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetyl chloride / methanol / 1 h / 20 °C / Inert atmosphere

2.1: triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

4.1: sodium hydrogencarbonate; ozone / dichloromethane; methanol / -78 - 0 °C / Inert atmosphere

4.2: 3 h / 20 °C / Inert atmosphere

5.1: triphenylphosphine / acetonitrile / 72 h / 70 °C / Sealed tube; Inert atmosphere

5.2: 6 h / 70 °C / Sealed tube; Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / methanol / 0.5 h / 20 °C / 760.05 Torr / Inert atmosphere

7.1: potassium hydroxide; water / methanol / 12 h / 20 °C / Inert atmosphere

8.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C / Inert atmosphere

With sodium azide; palladium 10% on activated carbon; water; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; acetyl chloride; triphenylphosphine; potassium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201508906