(R)-3-(1-(2-aminophenyl)-8-ethyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoic acid

Base Information

• Chemical Name: (R)-3-(1-(2-aminophenyl)-8-ethyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoic acid
• CAS No.: 197141-94-9
• Molecular Formula: C₁₉H₂₄N₂O₂
• Molecular Weight: 312.412
• Mol file: 197141-94-9.mol

Synonyms:(R)-3-(1-(2-aminophenyl)-8-ethyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoic acid

Chemical Property of (R)-3-(1-(2-aminophenyl)-8-ethyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(1-(2-aminophenyl)-8-ethyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoic acid

There total 52 articles about (R)-3-(1-(2-aminophenyl)-8-ethyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-(+)-1-(2-aminophenyl)-8-ethyl-8-[2-(aminocarbonyl)ethyl]-5,6,7,8-dihydroindolizine → (R)-3-(1-(2-aminophenyl)-8-ethyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoic acid (197141-94-9)

Guidance literature:

With potassium hydroxide; In methanol; at 0 - 20 ℃; for 0.5h;

DOI:10.1002/anie.201303067

Reference yield:

(R)-methyl 3-(8-ethyl-1-(2-nitrophenyl)-5,6,7,8-tetrahydroindolizin-8-yl)propanoate → (R)-3-(1-(2-aminophenyl)-8-ethyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoic acid (197141-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere

2: potassium hydroxide / methanol; water / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium hydroxide; In methanol; water;

DOI:10.1002/anie.201405842

Reference yield:

C21H26N2O3 → (R)-3-(1-(2-aminophenyl)-8-ethyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoic acid (197141-94-9)

Guidance literature:

With potassium hydroxide; In methanol; water; at 50 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02210

upstream raw materials:

(R)-(-)-1-ethyl-2-oxocyclohexane-1-propanoic acid methyl ester

(R)-(-)-1-ethyl-2-oxo-3-cyclohexene-1-propionic acid methyl ester

methyl 3-((3R)-3-ethyl-2-oxo-7-oxa-bicyclo[4.1.0]heptan-3-yl)propanoate

Downstream raw materials:

(±)-rhazinilam

rhazinilam

3-{(R)-1-[2-((S)-2-Amino-3-methyl-butyrylamino)-phenyl]-8-ethyl-5,6,7,8-tetrahydro-indolizin-8-yl}-propionic acid

3-{(R)-1-[2-(2-Amino-acetylamino)-phenyl]-8-ethyl-5,6,7,8-tetrahydro-indolizin-8-yl}-propionic acid