(S)-2-Amino-2-(3,5-dihydroxyphenyl)aceticacidhydrate

Base Information

Chemical Name:(S)-2-Amino-2-(3,5-dihydroxyphenyl)aceticacidhydrate
CAS No.:162870-29-3
Molecular Formula:C₈H₉NO₄
Molecular Weight:183.164
Hs Code.:2922509090
Wikipedia:Dihydroxyphenylglycine
Mol file:162870-29-3.mol

Synonyms:3,4-dihydroxyphenylglycol;3,4-dihydroxyphenylglycol , DL-;DHPG;dihydroxyphenylethylene glycol;dihydroxyphenylethylene glycol, (+-)-isomer;dihydroxyphenylethylene glycol, (S)-isomer;dihydroxyphenylglycine;DOPEG

Suppliers and Price of (S)-2-Amino-2-(3,5-dihydroxyphenyl)aceticacidhydrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-3,5-Dihydroxylphenylglycine
5mg
$ 85.00

TRC
(S)-3,5-Dihydroxylphenylglycine
1mg
$ 50.00

Tocris
(S)-3,5-DHPG ≥98%(HPLC)
5
$ 160.00

Tocris
(S)-3,5-DHPG ≥98%(HPLC)
10
$ 300.00

Sigma-Aldrich
(S)-3,5-Dihydroxyphenylglycine hydrate ≥98% (HPLC), powder
5mg
$ 218.00

Sigma-Aldrich
(S)-3,5-Dihydroxyphenylglycine hydrate ≥98% (HPLC), powder
10mg
$ 413.00

Medical Isotopes, Inc.
(S)-3,5-Dihydroxylphenylglycine
100 mg
$ 2200.00

Medical Isotopes, Inc.
(S)-3,5-Dihydroxylphenylglycine
1 mg
$ 550.00

ChemScene
(S)-3,5-DHPG ≥99.0%
5mg
$ 180.00

Cayman Chemical
(S)-3,5-DHPG ≥98%
5mg
$ 101.00

Total 18 raw suppliers

Chemical Property of (S)-2-Amino-2-(3,5-dihydroxyphenyl)aceticacidhydrate

Chemical Property:

Boiling Point:448.8±33.0 °C(Predicted)
PKA:1.77±0.10(Predicted)
PSA：103.78000
Density:1.550±0.06 g/cm3(Predicted)
LogP:0.88250
Storage Temp.:−20°C
Solubility.:Aqueous Base (Very Slightly, Sonicated), Methanol (Slightly), Water (Slightly, H
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:201.06372245
Heavy Atom Count:14
Complexity:187

Purity/Quality:

97% ^*data from raw suppliers

(S)-3,5-Dihydroxylphenylglycine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=C(C=C1O)O)C(C(=O)O)N.O
Isomeric SMILES:C1=C(C=C(C=C1O)O)[C@@H](C(=O)O)N.O
Uses (S)-3,5-Dihydroxylphenylglycine is a potent agonist of group I metabotropic glutamate receptors mGluR1 and mGluR5. (S)-3,5-Dihydroxylphenylglycine have been utilized for the treatment of neuronal inju ry and cognitive enhancement. (S)-3,5-Dihydroxylphenylglycine is a potent agonist of group I metabotropic glutamate receptors mGluR1 and mGluR5. (S)-3,5-Dihydroxylphenylglycine have been utilized for the treatment of neuronal injury and cognitive enhancement. (S)-3,5-Dihydroxyphenylglycine hydrate has been used: as mGluR1/5?agonist for metabotropic glutamate receptor 1 (mGluR1/5) activation in synaptoneurosomal preparations in ACSF for DHPG stimulation to inject into basolateral amygdala to study its effect on memory expression

Technology Process of (S)-2-Amino-2-(3,5-dihydroxyphenyl)aceticacidhydrate

There total 9 articles about (S)-2-Amino-2-(3,5-dihydroxyphenyl)aceticacidhydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: kistamicin A

: 556-02-5,18875-48-4,25619-78-7,30704-25-7
tyrosine

: 146255-66-5,162870-29-3,19641-83-9
2-amino-2-(3,5-dihydroxyphenyl)acetic acid

: 155435-50-0
Amino-{3-[4-(amino-carboxy-methyl)-2-chloro-phenoxy]-4-hydroxy-phenyl}-acetic acid

: 2-Amino-3-{6-[3-[4-(2-amino-2-carboxy-ethyl)-phenoxy]-5-(amino-carboxy-methyl)-2-hydroxy-phenyl]-1H-indol-3-yl}-propionic acid

Guidance literature:: With hydrogenchloride; mercaptoacetic acid; at 110 ℃; for 24h;
DOI:10.7164/antibiotics.46.1812

Reference yield:

: 1208237-23-3
2-amino-2-(3,5-dihydroxyphenyl)acetonitrile

: 162870-29-3,19641-83-9
(S)-3,5-dihydroxyphenylglycine

Guidance literature:: With α-aminonitrilase NIT191 from Burkholderia xenovorans; In aq. phosphate buffer; at 30 ℃; pH=7.3; stereospecific reaction; Enzymatic reaction;
DOI:10.1016/j.molcatb.2014.05.019

Reference yield:

: 1208237-23-3
2-amino-2-(3,5-dihydroxyphenyl)acetonitrile

: 162870-29-3,19641-83-9
(R)-3,5-DHPG

Guidance literature:: With α-aminonitrilase NIT28 from Sphingomonas wittichii; In aq. phosphate buffer; at 30 ℃; pH=7.3; stereospecific reaction; Enzymatic reaction;
DOI:10.1016/j.molcatb.2014.05.019