Technology Process of C15H16N2O3
There total 5 articles about C15H16N2O3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diazoacetic acid ethyl ester;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
Inert atmosphere;
3-(2-methylphenyl)cyclobuten-1-one;
In
tetrahydrofuran;
at -75 - 20 ℃;
for 1.25h;
Inert atmosphere;
DOI:10.1021/ol301474g
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1,2-dimethoxyethane; diethyl ether / 1.75 h / 0 - 20 °C / Inert atmosphere
2.1: N,N,N,N,-tetramethylethylenediamine; acetic acid; zinc / ethanol / 1.25 h / 0 - 20 °C / Inert atmosphere
3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
3.2: 1.25 h / -75 - 20 °C / Inert atmosphere
With
N,N,N,N,-tetramethylethylenediamine; acetic acid; zinc; lithium diisopropyl amide;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol;
DOI:10.1021/ol301474g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N,N,N,N,-tetramethylethylenediamine; acetic acid; zinc / ethanol / 1.25 h / 0 - 20 °C / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 1.25 h / -75 - 20 °C / Inert atmosphere
With
N,N,N,N,-tetramethylethylenediamine; acetic acid; zinc; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol;
DOI:10.1021/ol301474g
