4-[3-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-2,3-dihydro-benzofuran-7-yl]-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole

Base Information

Chemical Name:4-[3-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-2,3-dihydro-benzofuran-7-yl]-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole
CAS No.:405519-79-1
Molecular Formula:C₅₁H₅₈N₂O₅Si₂
Molecular Weight:835.203
Hs Code.:

4-[3-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-3-phenyl-2,3-dihydro-benzofuran-7-yl]-3-[2-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1<i>H</i>-indole

Synonyms:4-[3-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-2,3-dihydro-benzofuran-7-yl]-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole

Suppliers and Price of 4-[3-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-2,3-dihydro-benzofuran-7-yl]-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[3-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-2,3-dihydro-benzofuran-7-yl]-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[3-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-2,3-dihydro-benzofuran-7-yl]-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole

There total 10 articles about 4-[3-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-2,3-dihydro-benzofuran-7-yl]-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95-56-7
2-hydroxybromobenzene

: 405519-79-1
4-[3-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-2,3-dihydro-benzofuran-7-yl]-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole

Guidance literature:: Multi-step reaction with 8 steps

1: 42 percent / aq. H₂SO₄ / 45 h / Heating

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: Yb(OTf)3 / tetrahydrofuran; H₂O / 24 h / 25 °C

4: 95 percent / imidazole / dimethylformamide / 6 h / 25 °C

5: 95 percent / LiBH₄ / tetrahydrofuran / 4 h / 25 °C

6: 95 percent / 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Heating

7: 70 percent / KOAc / [Pd(dppf)Cl₂]*CH₂Cl₂ / dimethylsulfoxide / 6 h / 90 °C

8: 66 percent / K₂CO₃ / [Pd(dppf)Cl₂]*CH₂Cl₂ / 1,2-dimethoxy-ethane / 8 h / 110 °C

With 1H-imidazole; lithium borohydride; sulfuric acid; potassium acetate; potassium carbonate; triethylamine; 1,1'-carbonyldiimidazole; ytterbium(III) triflate; [1,1'-bis(diphenylphosphino)-ferrocene]palladium(II) chloride-dichlormethane complex; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/1521-3773(20011217)40:24<4705::AID-ANIE4705>3.0.CO;2-D

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 405519-79-1
4-[3-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-2,3-dihydro-benzofuran-7-yl]-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / imidazole / dimethylformamide / 6 h / 25 °C

2: 95 percent / LiBH₄ / tetrahydrofuran / 4 h / 25 °C

3: 95 percent / 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Heating

4: 70 percent / KOAc / [Pd(dppf)Cl₂]*CH₂Cl₂ / dimethylsulfoxide / 6 h / 90 °C

5: 66 percent / K₂CO₃ / [Pd(dppf)Cl₂]*CH₂Cl₂ / 1,2-dimethoxy-ethane / 8 h / 110 °C

With 1H-imidazole; lithium borohydride; potassium acetate; potassium carbonate; 1,1'-carbonyldiimidazole; [1,1'-bis(diphenylphosphino)-ferrocene]palladium(II) chloride-dichlormethane complex; In tetrahydrofuran; 1,2-dimethoxyethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/1521-3773(20011217)40:24<4705::AID-ANIE4705>3.0.CO;2-D

Reference yield:

: 611-71-2,611-72-3,17199-29-0,90-64-2
MANDELIC ACID

: 405519-79-1
4-[3-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-2,3-dihydro-benzofuran-7-yl]-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole

Guidance literature:: Multi-step reaction with 8 steps

1: 42 percent / aq. H₂SO₄ / 45 h / Heating

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: Yb(OTf)3 / tetrahydrofuran; H₂O / 24 h / 25 °C

4: 95 percent / imidazole / dimethylformamide / 6 h / 25 °C

5: 95 percent / LiBH₄ / tetrahydrofuran / 4 h / 25 °C

6: 95 percent / 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Heating

7: 70 percent / KOAc / [Pd(dppf)Cl₂]*CH₂Cl₂ / dimethylsulfoxide / 6 h / 90 °C

8: 66 percent / K₂CO₃ / [Pd(dppf)Cl₂]*CH₂Cl₂ / 1,2-dimethoxy-ethane / 8 h / 110 °C

With 1H-imidazole; lithium borohydride; sulfuric acid; potassium acetate; potassium carbonate; triethylamine; 1,1'-carbonyldiimidazole; ytterbium(III) triflate; [1,1'-bis(diphenylphosphino)-ferrocene]palladium(II) chloride-dichlormethane complex; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/1521-3773(20011217)40:24<4705::AID-ANIE4705>3.0.CO;2-D