Methanesulfonic acid 3,5-dibromo-2,4-dimethoxy-benzyl ester

Base Information

• Chemical Name: Methanesulfonic acid 3,5-dibromo-2,4-dimethoxy-benzyl ester
• CAS No.: 120185-72-0
• Molecular Formula: C₁₀H₁₂Br₂O₅S
• Molecular Weight: 404.076
• Mol file: 120185-72-0.mol

Synonyms:Methanesulfonic acid 3,5-dibromo-2,4-dimethoxy-benzyl ester

Chemical Property of Methanesulfonic acid 3,5-dibromo-2,4-dimethoxy-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Methanesulfonic acid 3,5-dibromo-2,4-dimethoxy-benzyl ester

There total 5 articles about Methanesulfonic acid 3,5-dibromo-2,4-dimethoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanesulfonyl chloride (124-63-0) + (3,5-Dibromo-2,4-dimethoxy-phenyl)-methanol (120185-71-9) → Methanesulfonic acid 3,5-dibromo-2,4-dimethoxy-benzyl ester (120185-72-0)

Guidance literature:

In pyridine; at 0 ℃;

DOI:10.1016/S0040-4039(00)95396-6

Reference yield:

methyl 3,5-dibromo-2,4-dimethoxybenzoate (39503-48-5) → Methanesulfonic acid 3,5-dibromo-2,4-dimethoxy-benzyl ester (120185-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / DIBAL-H / diethyl ether / -40 °C

2: 90 percent / pyridine / 0 °C

With diisobutylaluminium hydride; In pyridine; diethyl ether;

DOI:10.1016/S0040-4039(00)95396-6

Reference yield:

4-hydroxysalicylic acid (89-86-1) → Methanesulfonic acid 3,5-dibromo-2,4-dimethoxy-benzyl ester (120185-72-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / Br₂ / acetic acid / 40 °C

2: 90 percent / diethyl ether / 0 °C

3: 98 percent / K₂CO₃ / acetone / Heating

4: 90 percent / DIBAL-H / diethyl ether / -40 °C

5: 90 percent / pyridine / 0 °C

With bromine; diisobutylaluminium hydride; potassium carbonate; In pyridine; diethyl ether; acetic acid; acetone;

DOI:10.1016/S0040-4039(00)95396-6

upstream raw materials:

methanesulfonyl chloride

(3,5-Dibromo-2,4-dimethoxy-phenyl)-methanol

4-hydroxysalicylic acid

3,5-Dibromo-2,4-dihydroxy-benzoic acid methyl ester

Downstream raw materials:

3,5-dibromo-2,4-dimethoxyphenylacetonitrile

(3,5-Dibromo-2,4-dimethoxy-phenyl)-acetic acid